DOI: 10.1016/j.jcou.2017.12.012
Scopus记录号: 2-s2.0-85039166106
论文题名: Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming
作者: Goimil L. ; Jaeger P. ; Ardao I. ; Gómez-Amoza J.L. ; Concheiro A. ; Alvarez-Lorenzo C. ; García-González C.A.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 24 起始页码: 89
结束页码: 98
语种: 英语
英文关键词: Bone regeneration
; Compressed CO2 foaming
; Dexamethasone
; Polymeric scaffolds
; Stability under storage
Scopus关键词: Biopolymers
; Bone
; Carbon dioxide
; Degradation
; Polymers
; Stability
; Bone regeneration
; CO2 foaming
; Design and optimization
; Dexamethasones
; Physico-chemical and mechanical properties
; Poly (epsiloncaprolactone)
; Poly(lactic-co-glycolic acid)
; Polymeric scaffold
; Scaffolds (biology)
英文摘要: Compressed CO2 foaming allows for obtaining porous solid drug-loaded scaffolds for regenerative medicine under mild conditions and in the absence of organic solvents. However, a precise process design and optimization as well as certain modifications of the technology are still needed to tackle certain limitations like the control of the porosity of scaffolds from certain low molecular weight biopolymers. Besides, stability under storage is a critical quality attribute to define the usefulness of scaffolds. In the particular case of bone scaffolds, the information on this regard is still very limited and strongly dependent on each particular composition and architecture. In order to gain an insight into this issue, scaffolds composed of poly(lactic-co-glycolic acid) (PLGA) and poly(ε-caprolactone) (PCL) as polymeric matrix, with and without pre-gelified starch (St) as release-controlling agent and dexamethasone (DXMT) as bioactive compound were designed and prepared by a modified compressed CO2 foaming technique (26 °C, 60 bar) and assessed regarding stability under storage. The scaffolds were stored at 25 °C and 65% relative humidity (zone II ICH-climatic conditions for Europe, USA and Japan) for up to three months to determine the effect of storage on the structural, physicochemical and mechanical properties, and DXMT release. Changes in the scaffolds point out the importance of stability assays and storage conditions. Namely, a decrease in the viscoelastic moduli of the scaffolds and a faster degradation rate were observed after prolonged storage periods. DXMT release from the scaffolds was erosion-controlled and thus modified for scaffolds stored for longer time periods. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111988
Appears in Collections: 气候减缓与适应
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作者单位: Departamento de Farmacología, Farmaciay Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, E-15782, Spain; Hamburg University of Technology (TUHH), Eißendorfer Str. 38, Hamburg, D-21073, Germany; BioFarma Research Group, Centro Singular de Investigación en Medicina Moleculary Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, E-15782, Spain
Recommended Citation:
Goimil L.,Jaeger P.,Ardao I.,et al. Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming[J]. Journal of CO2 Utilization,2018-01-01,24