globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1307725
论文题名:
Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)
作者: Kateryna B. Fuks; 1 Gudrun Weinmayr; 1; 2 Maria Foraster; 3; 4; 5 Julia Dratva; 6; 7 Regina Hampel; 8 Danny Houthuijs; 9 Bente Oftedal; 10 Anna Oudin; 11 Sviatlana Panasevich; 12 Johanna Penell; 13 Johan N. Sommar; 11 Mette Sørensen; 14 Pekka Tiittanen; 15 Kathrin Wolf; 8 Wei W. Xun; 16; 17 Inmaculada Aguilera; 3; 4 Xavier Basagaña; 3; 4 Rob Beelen; 18 Michiel L. Bots; 19 Bert Brunekreef; 18; 19 H. Bas Bueno-de-Mesquita; 9; 20 Barbara Caracciolo; 21 Marta Cirach; 3; 4; 22 Ulf de Faire; 13 Audrey de Nazelle; 3; 23 Marloes Eeftens; 18 Roberto Elosua; 22 Raimund Erbel; 24 Bertil Forsberg; 11 Laura Fratiglioni; 21; 25 Jean-Michel Gaspoz; 26; 27 Agneta Hilding; 28 Antti Jula; 29 Michal Korek; 13 Ursula Krämer; 1 Nino Künzli; 6; 7 Timo Lanki; 15 Karin Le; er; 13 Patrik K.E. Magnusson; 30 Jaume Marrugat; 22; 31 Mark J. Nieuwenhuijsen; 3; 4; 22 Claes-Göran Östenson; 28 Nancy L. Pedersen; 30 Göran Pershagen; 13 Harish C. Phuleria; 6; 7 Nicole M. Probst-Hensch; 6; 7 Ole Raaschou-Nielsen; 14 Emmanuel Schaffner; 6; 7 Tamara Schikowski; 1; 6; 7 Christian Schindler; 6; 7 Per E. Schwarze; 10 Anne J. Søgaard; 12 Dorothea Sugiri; 1 Wim J.R. Swart; 9 Ming-Yi Tsai; 6; 7 Anu W. Turunen; 15 Paolo Vineis; 16 Annette Peters; 8; Barbara Hoffmann1; 32
刊名: Environmental Health Perspectives
ISSN: 0091-7497
出版年: 2014
卷: Volume 122, 期:Issue 9
起始页码: 896
语种: 英语
英文摘要: Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific.

Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations.

Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis.

Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated.

Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.
URL: https://ehp.niehs.nih.gov/1307725
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12826
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; 2Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany; 3Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 4CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; 5Universitat Pompeu Fabra, Barcelona, Spain; 6Swiss Tropical and Public Health Institute, Basel, Switzerland; 7University of Basel, Basel, Switzerland; 8Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; 9National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; 10Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; 11Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; 12Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway; 13Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 14Danish Cancer Society Research Center, Copenhagen, Denmark; 15Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland; 16Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom; 17Department of Epidemiology and Public Health, University College London, London, United Kingdom; 18Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; 19Julius Center for Primary Care and Health Sciences, University Medical Center Utrecht, Utrecht, the Netherlands; 20School of Public Health, Imperial College London, London, United Kingdom; 21Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; 22IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; 23Centre for Environmental Policy, Imperial College London, United Kingdom; 24West German Heart Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 25Stockholm Gerontology Research Center, Stockholm, Sweden; 26Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; 27Faculty of Medicine, University of Geneva, Geneva, Switzerland; 28Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 29Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland; 30Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 31Department of Research in Inflammatory and Cardiovascular Disorders (RICAD), IMIM-Hospital del Mar, Barcelona, Spain; 32Medical School, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany

Recommended Citation:
Kateryna B. Fuks,1 Gudrun Weinmayr,1,et al. Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)[J]. Environmental Health Perspectives,2014-01-01,Volume 122(Issue 9):896
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