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Urban agriculture is becoming a timely environmental friendly practice to strengthen cities' resilience to climate change. However, there is a lack of academic literature regarding the thermodynamic potential of interior urban agriculture. Furthermore, there is always a need to develop, from scratch, an updated methodological approach that aims to assist architects of conceiving such specific thermodynamically complex interior environments. In this paper, urban space is identified as a flow system', and Bejan's constructal law of generation of flow structure is used to morph and discover the system flow architecture that offers greater global performance (greater access to what flows). More precisely, a macroscale thermodynamic model of spherical urban greenhouse form with double thermal envelope has been developed while the methodological approach resulted in the definition of a decisional flowchart that can be reproduced by other researchers. On the basis of this macroscale constructal model, the present paper proposes reduced models that link thermodynamic and geometric parameters in an accurate manner and can be used at early design stages for pedagogic and qualitative optimization purposes, integrating urban farming to architectural programming.