Sea salt aerosol (SSA) is one of the most important aerosol components in atmosphere, which plays very important role in atmospheric environment and climate change. The regional climate and chemistry modeling system RegCCMS was further developed and applied to investigate the spatial and temporal characteristics of sea salt aerosol as well as its direct effect. Here we present numerical simulations on sea salt aerosol concentrations and then its direct climate responses in January, April, July and October 2006, representing for four seasons. The annual mean concentration of SSA over ocean areas of East Asia reaches 14.69 mug·m~(-3). The maximum concentration of 26.27 mug·m~(-3) occurs in winter, while the minimum concentration of 7.59 mug·m~(-3) occurs in summer. The results indicate that the spatial and temporal distribution of SSA shows obvious seasonal variation. The high value center of SSA concentration appears in the South China Sea in winter and in the Yellow Sea in summer. The annual direct radiative forcing at the top of atmosphere of SSA in this area is estimated to be -2.35W·m~(-2) and -1.17 W·m~(-2) for clear sky and all sky, respectively. The direct climate effects of SSA lead to cooling over the coastal land and islands. For Taiwan, the cooling is -1.0940 K, -0.0083 K in July and January, respectively. For the coastal land, the coolings in July and January are -0.1330 K and -0.0142 K, respectively.