DOI: 10.1016/j.jcou.2017.01.020
Scopus记录号: 2-s2.0-85012082572
论文题名: Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide
作者: Chen C.-T. ; Lee C.-A. ; Tang M. ; Chen Y.-P.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2017
卷: 18 语种: 英语
英文关键词: Active pharmaceutical ingredient
; Pyridin-4-amine
; RESS
; Solute solubility
; Supercritical carbon dioxide
Scopus关键词: Carbon dioxide
; Dissolution
; Electromagnetic wave emission
; Particle size
; Solubility
; Active pharmaceutical ingredients
; Experimental investigations
; Neurological disorders
; Optimal operation conditions
; Rapid expansion of supercritical solutions
; RESS
; Solute solubility
; Supercritical carbon dioxides
; Supercritical fluid extraction
英文摘要: Graphical abstract: Novel solute solubility data of pyridin-4-amine (C5H6N2, also known as 4-aminopyridine or fampridine) in supercritical carbon dioxide are measured in this study. This compound is an active pharmaceutical ingredient (API) for the treatment of neurological disorder, and the Alzheimer’s disease. The solubility data at three isotherms (308.2, 318.2 and 328.2K) are reported for pressures from 10 to 22MPa. These solubility results are ranged from 2×10−5 to 2×10−4mol fraction, and are confirmed as thermodynamically consistent. We further apply the rapid expansion of supercritical solution (RESS) process to micronize this API. At our optimal operation condition, the original API with a mean particle size of 532.3±236.5μm is micronized to 0.32±0.07μm. The RESS processed products are much more uniform and nearly spherical amorphous particles. Finally, an in vitro dissolution test illustrates an enhanced dissolution rate by 2.9 times for the micronized pyridin-4-amine. © 2017 Elsevier Ltd.
资助项目: Ministry of Science and Technology, Taiwan
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/52784
Appears in Collections: 影响、适应和脆弱性
There are no files associated with this item.
Recommended Citation:
Chen C.-T.,Lee C.-A.,Tang M.,et al. Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide[J]. Journal of CO2 Utilization,2017-01-01,18