| 项目编号: | BB/L019345/1
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| 项目名称: | Molecular mechanism regulating MAPKs activation within resistance complexes |
| 作者: | Vardis Ntoukakis
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| 承担单位: | University of Warwick
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| 批准年: | 2013
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| 开始日期: | 2014-28-10
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| 结束日期: | 2017-27-10
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| 资助金额: | GBP366274
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| 资助来源: | UK-BBSRC
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| 项目类别: | Research Grant
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| 国家: | UK
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| 语种: | 英语
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| 特色学科分类: | Agri-environmental science
; Plant & crop science
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| 英文摘要: | A major challenge for the coming years is to provide food for an increasing number of people. Global demand for natural resources and the decreasing area of arable land are driving up the costs of energy and food. Therefore, it is of great importance to increase current crop production in a sustainable manner. Minimizing agricultural losses from pathogens will substantially increase crop yield and decrease the cost of food production.
During the last decades the field of plant-microbe interactions has made impressive progress revealing the basic architecture of the immune system. We now know that through evolution, plants have developed resistance (R) genes encoding immune receptors that recognize pathogen-derived elicitor molecules to activate immunity. Currently our main strategy to combat diseases in field conditions is the deployment of resistance (R) genes in crops. This resistance is often rapidly overcome in agriculture by evolving pathogen populations. However, our understanding of R genes mediated plant immunity is still in its infancy, and many important questions remain open. There is very little known about host immune mechanisms beyond pathogen recognition by R proteins. Mitogen-activated protein kinases (MAPKs) are one group of enzymes activated by R proteins. In eukaryotes, MAPKs exist in cascades that are necessary for functional immunity. R proteins can initiate activation of MAPKs cascades but the molecular mechanisms controlling this activation are completely unknown. Understanding the molecular mechanisms bridging the gap between activated R proteins and downstream MAPKs will be a vital step into engineering plants with durable resistance.
In work leading to this proposal we identified MAPKs as part of an R protein complex in tomato. This is the first time that MAPKs have been shown to be part of a resistance complex and gives us a clear picture of a molecular mechanism bridging the gap between activated R proteins and downstream signaling in a crop plant. This proposal aims to use this tomato R protein complex as a model for the characterization of the molecular mechanisms regulating MAPKs activation within the resistance complexes. We will use this knowledge to investigate the existence of a similar mechanism in other R protein complexes initially in the model plant Arabidopsis thaliana and in future work in crop plants |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/101736
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| Appears in Collections: | 科学计划与规划
气候变化与战略
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作者单位: | University of Warwick
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| Recommended Citation: | |
Vardis Ntoukakis. Molecular mechanism regulating MAPKs activation within resistance complexes. 2013-01-01.
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