| 项目编号: | NE/K00686X/1
|
| 项目名称: | Towards commercialising a hybrid nanosensor for screening dispersed nanoparticles and heavy metal ions in natural waters |
| 作者: | Laurence Andrew Nelson
|
| 承担单位: | University of Leeds
|
| 批准年: | 2012
|
| 开始日期: | 2013-04-05
|
| 结束日期: | 2014-03-02
|
| 资助金额: | GBP79860
|
| 资助来源: | UK-NERC
|
| 项目类别: | Research Grant
|
| 国家: | UK
|
| 语种: | 英语
|
| 特色学科分类: | Biomolecules & biochemistry 
; (20%)
; Chemical measurement 
; (40%)
; Pollution, waste & resources 
; (40%)
|
| 英文摘要: | The problem:
The use of engineered nanoparticles (NP) in cosmetics, pharmaceuticals, sensors and many other commercial applications has been growing exponentially over the past decade. Because of their increasing application many NP are discharged to the watercourse both by industrial companies and through domestic use. The technology for monitoring the environmental impact of these materials, particularly in aquatic systems, is not well developed. It is not only sufficient to be able to determine the NP in water but also it is crucial to have some understanding of their toxicity or biological activity. At the same time, a high throughput screener is urgently required to report on the biomembrane activity (ability to bind to/adsorb on/penetrate biological membranes) of different NP and/or products containing NP dispersed in water. A screening system for NP is therefore required which reports routinely on the level of biologically active NP in raw, waste and drinking waters. At the same time the presence of heavy metal ions in water is always a concern due to their implicit toxicity. These heavy metal ions can be derived from industrial and/or domestic use and in spite of the tremendous advances in the analysis of heavy metal ions in water in the past 50 years, there is currently no routine heavy metal ion screener available for natural and potable waters. A combined NP and heavy metal ion screener therefore would have immediate application in any organisation concerned about the quality of water which comes into contact with human activity.
Addressing the problem:
The proposed technology offers a device which has a dual capability as follows: (1) To screen waters for NP which are biomembrane active and hence are putatively toxic and, (2) To detect toxic heavy metal ions (Cu2+, Pb2+, Cd2+ and Zn2+) in water. The system can also be used to test samples of NP or products containing NP dispersed in water for biomembrane activity. The screening for NP in water is rapid, on-line and high throughput and takes 10 minutes to test each sample. Similarly heavy metal ions in the water can be measured together simultaneously and quantitatively. The NP screener works by looking at the interaction of NP with a phospholipid layer coated on a chip based Pt/Hg microelectrode in a flow cell. This is a development of a previous technology which uses the same device to screen waters for biomembrane active compounds. The heavy metal ions are determined using anodic stripping voltammetry which is a well established analytical technique. The development of the chip-based Pt/Hg electrode in flow cell with flow injection techniques enables both techniques to be used in a high throughput configuration. The switchover from one technique to the other can be readily software controlled.
Benefits which end-users will derive by adopting it:
(1) Screening waters for the presence of biomembrane active NP
(2) Screening products containing NP dispersed in water for biomembrane activity
(3) Screening commercially produced NP dispersed in water for biomembrane activity
(4) Detecting, identifying and quantitatively measuring toxic heavy metal ions in water |
| 资源类型: | 项目
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/102371
|
| Appears in Collections: | 科学计划与规划
气候变化与战略
|
|
There are no files associated with this item.
|
|
作者单位: | University of Leeds
|
| Recommended Citation: | |
Laurence Andrew Nelson. Towards commercialising a hybrid nanosensor for screening dispersed nanoparticles and heavy metal ions in natural waters. 2012-01-01.
|
|
|