DOI: 10.1111/ele.12455
Scopus记录号: 2-s2.0-84946415384
论文题名: Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution
作者: Zurita-Gutiérrez Y.H. ; Lion S.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2015
卷: 18, 期: 8 起始页码: 779
结束页码: 789
语种: 英语
英文关键词: Dispersal
; Epidemiology
; Host-parasite interactions
; Kin selection
; Vaccination
; Virulence management
Scopus关键词: epidemiology
; heterogeneity
; host-parasite interaction
; kin selection
; life history trait
; spatial distribution
; vaccination
; virulence
; vaccine
; biological model
; evolution
; genetics
; host pathogen interaction
; population genetics
; virulence
; Biological Evolution
; Genetics, Population
; Host-Pathogen Interactions
; Models, Biological
; Vaccines
; Virulence
英文摘要: Natural host-parasite interactions exhibit considerable variation in host quality, with profound consequences for disease ecology and evolution. For instance, treatments (such as vaccination) may select for more transmissible or virulent strains. Previous theory has addressed the ecological and evolutionary impact of host heterogeneity under the assumption that hosts and parasites disperse globally. Here, we investigate the joint effects of host heterogeneity and local dispersal on the evolution of parasite life-history traits. We first formalise a general theoretical framework combining variation in host quality and spatial structure. We then apply this model to the specific problem of parasite evolution following vaccination. We show that, depending on the type of vaccine, spatial structure may select for higher or lower virulence compared to the predictions of non-spatial theory. We discuss the implications of our results for disease management, and their broader fundamental relevance for other causes of host heterogeneity in nature. © 2015 John Wiley & Sons Ltd/CNRS. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107889
Appears in Collections: 气候减缓与适应
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作者单位: Centre d'Écologie Fonctionnelle et Évolutive (CEFE), UMR 5175, CNRS - Université de Montpellier - Université Paul-Valéry Montpellier - EPHE., 1919 route de Mende, Montpellier Cedex 5, France
Recommended Citation:
Zurita-Gutiérrez Y.H.,Lion S.. Spatial structure, host heterogeneity and parasite virulence: Implications for vaccine-driven evolution[J]. Ecology Letters,2015-01-01,18(8)