DOI: 10.1016/j.jcou.2018.03.017
Scopus记录号: 2-s2.0-85045891773
论文题名: Supercritical CO2 fluid-assisted cross-linking of porcine acellular dermal matrix by ethylene glycol diglycidyl ether
作者: Chen Y. ; Dan N. ; Dan W. ; Yu G.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 25 起始页码: 264
结束页码: 274
语种: 英语
英文关键词: Cross-linking
; Epoxy compound
; Porcine acellular dermal matrix
; Supercritical CO2 fluid
; Wound healing
Scopus关键词: Biocompatibility
; Carbon dioxide
; Cell culture
; Collagen
; Ethers
; Ethylene
; Ethylene glycol
; Polyols
; Acellular dermal matrixes
; Crosslinking reaction
; Enzymatic Degradation
; Epoxy compound
; Ethylene glycol diglycidyl ethers
; Physicochemical property
; Supercritical CO2
; Wound healing
; Crosslinking
英文摘要: In addition to the cross-linker, which has an impact on the properties of the materials being cross-linked, the reaction media can impact the reaction's effectiveness. In this study, porcine acellular dermal matrix (pADM), an aggregation of collagen fibers, was cross-linked by ethylene glycol diglycidyl ether (EGDE) in supercritical CO2 fluid (sc-CO2) reaction medium (EGDE-pADM). And pADM cross-linked in ethyl alcohol medium (EtOH-EGDE-pADM) was used as control. The physicochemical properties and biocompatibility of the cross-linked pADM were evaluated. The results showed that EGDE-pADM had improved thermal stability, hydrophilicity, mechanical strength, resistance to enzymatic degradation and pore structure compared with the uncross-linked pADM and EtOH- EGDE-pADM. And the improvement of scaffolds' properties was related to the pressure of sc-CO2. The EGDE-pADM had excellent biocompatibility both in vitro and in vivo; it improved the adhesion and proliferation of L929 fibroblast cells, especially when compared with EtOH-EGDE-pADM using organic solvent, and expedited the wound healing process. These findings indicate that the reaction medium had a certain influence on the properties and cytotoxicity of the cross-linked pADM, sc-CO2 fluid was proven to be a safe and reliable cross-linking reaction medium for collagen. © 2018 Published by Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111896
Appears in Collections: 气候减缓与适应
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作者单位: Key Laboratory for Leather Chemistry and Engineering, Education Ministry, Sichuan University, Chengdu Sichuan, 610065, China; Research Center of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China
Recommended Citation:
Chen Y.,Dan N.,Dan W.,et al. Supercritical CO2 fluid-assisted cross-linking of porcine acellular dermal matrix by ethylene glycol diglycidyl ether[J]. Journal of CO2 Utilization,2018-01-01,25