globalchange  > 气候减缓与适应
DOI: 10.1016/j.watres.2018.09.024
Scopus记录号: 2-s2.0-85053779569
论文题名:
Identification of a mutagenic chlorination by-product produced from (E)-1, 3-dichloropropene (a component of nematocide DD) by using high resolution LC/MS and multivariate analysis
作者: Takanashi H.; Abiru K.; Hama T.; Shinfuku Y.; Nakajima T.; Ohki A.; Ueda T.; Kondo T.; Matsushita T.; Kameya T.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 146
起始页码: 187
结束页码: 196
语种: 英语
英文关键词: 1,3-Dichloroacetone ; Correlation analysis ; Electric field type FT-MS ; Orthogonal projections to latent structures ; Regression analysis ; TOF-MS
英文摘要: The estimated domestic usage of DD (a typical nematocide) has been the greatest among all the agricultural chemicals in Japan. DD is involved in a document which is used to establish tap water quality standard in Japan. The document indicates that DD is potentially detectable in raw water for tap waters. DD in raw water will be treated with chlorine at waterworks, which raises concerns about formation of mutagenic chlorination by-products through the treatment. The objective of this work was to identify a mutagenic chlorination by-product by using high resolution mass spectrometers and multivariate analyses. Mutagenicity of the chlorination by-product was evaluated with the Ames Salmonella mutagenicity assay. (E)-1,3-Dichloropropene (DCP) was used as a model compound of DD. The mutagenicity of chlorine treated model aqueous solutions of DD increased with increasing chlorine dosages up to 3.00 mol-Cl2/mol-DCP. From the chlorine treated aqueous solutions of DD, 1,3-dichloroacetone (DCA) was identified as a major mutagen by a cochromatography with an authentic standard, precursor ion analyses and first-generation product ion analyses with the high resolution mass spectrometers. The mutagenicity of DCA against TA100 strain without microsomal activation was 160,000 net revertant colony/μmol (the toxicity equivalent factor was 0.14). Based on the mutagenicity of the chlorine treated DCP sample, the specific mutagenicity of DCA, and the DCA concentration in the sample, the mutagenic contribution of DCA to the chlorine treated DCP sample was calculated. High contribution (98%) clearly shows that DCA is a major mutagen in the chlorine treated DCP sample. Because the exploration of DCA was performed by using the unrealistic high concentration samples of DCP and chlorine, formation of DCA in the practical concentration samples (0-200 μg-DCP/L, 0.10 or 1.27 mg-Cl2/L) was examined. It was proven that DCA formation reaction takes place in the practical concentrations of DCA and chlorine. © 2018 Elsevier Ltd
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112380
Appears in Collections:气候减缓与适应

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作者单位: Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, Kagoshima, 890-0065, Japan; Department of Environmental Engineering, Faculty of Engineering, Hokkaido University, Sapporo, 060-8628, Japan; Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, Yokohama, 240-8501, Japan

Recommended Citation:
Takanashi H.,Abiru K.,Hama T.,et al. Identification of a mutagenic chlorination by-product produced from (E)-1, 3-dichloropropene (a component of nematocide DD) by using high resolution LC/MS and multivariate analysis[J]. Water Research,2018-01-01,146
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