DOI: 10.1016/j.watres.2018.03.036
Scopus记录号: 2-s2.0-85044139874
论文题名: Stability of alcohol and tobacco consumption biomarkers in a real rising main sewer
作者: Gao J. ; Li J. ; Jiang G. ; Yuan Z. ; Eaglesham G. ; Covaci A. ; Mueller J.F. ; Thai P.K.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 138 起始页码: 19
结束页码: 26
语种: 英语
英文关键词: Alcohol and tobacco
; Benchmarking
; Biomarker stability
; LC-MS/MS
; Wastewater-based epidemiology
Scopus关键词: Benchmarking
; Degradation
; Nicotine
; Sewers
; Stability
; Sulfur compounds
; Tobacco
; Uncertainty analysis
; Alcohol consumption
; Degradation rate
; Ethyl glucuronide
; Hydraulic retention time
; LC-MS/MS
; Population health
; Potential tool
; Tobacco consumption
; Biomarkers
; 3' hydroxycotinine
; acesulfame
; alcohol
; biological marker
; cotinine
; ethyl glucuronide
; ethyl sulfate
; nicotine
; rhodamine
; sulfate
; tracer
; unclassified drug
; alcohol
; biological marker
; cotinine
; diethyl sulfate
; glucuronic acid
; hydroxycotinine
; nicotine
; sulfate
; alcoholic beverage
; benchmarking
; biomarker
; degradation
; epidemiology
; experimental study
; food consumption
; liquid chromatography
; mass spectrometry
; sewer network
; tracer
; wastewater
; alcohol consumption
; Article
; conjugation
; degradation
; priority journal
; sewer
; tobacco consumption
; waste water
; analogs and derivatives
; analysis
; drinking behavior
; human
; metabolism
; tobacco use
; water pollutant
; Nicotiana tabacum
; Alcohol Drinking
; Biomarkers
; Cotinine
; Ethanol
; Glucuronates
; Humans
; Nicotine
; Sulfuric Acid Esters
; Tobacco Use
; Waste Water
; Water Pollutants, Chemical
英文摘要: Since alcohol and tobacco consumption are among the leading causes of population health harm, it is very important to understand the consumption behaviour to develop effective harm reduction strategies. Wastewater-based epidemiology (WBE) is a potential tool for estimating their consumption, but there are several uncertainties that need to be determined, including the stability of biomarkers in the sewer. Utilizing a real rising main sewer, this study investigated the stability of alcohol and tobacco consumption biomarkers. Rhodamine and acesulfame were used as flow tracer and benchmarker to understand the transportation of wastewater in the sewer with a hydraulic retention time between 2.7 and 5.0 h. Ethyl sulphate (EtS) and ethyl glucuronide (EtG), two biomarkers of alcohol consumption, were found to have different in-sewer stability, with EtS much more stable than EtG. The degradation rate of EtS is approximately 8% per hour, while EtG has a half-life of 1.9 h. Formation of nicotine, cotinine and trans-3′-hydroxycotinine, three biomarkers for tobacco consumption, was observed during the experiment, probably due to deconjugation of their glucuronide chemicals. The deconjugation process has prevented the determination of actual stability of the three chemicals. However, it is suggested that cotinine is relatively stable, while nicotine and trans-3′-hydroxycotinine degrade to a certain degree in the sewer system. According to our findings, the in-sewer degradation is more important during the interpretation of alcohol consumption estimation than for tobacco consumption estimation. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112781
Appears in Collections: 气候减缓与适应
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作者单位: Queensland Alliance for Environmental Health Sciences, The University of Queensland, Brisbane, QLD 4108, Australia; Advanced Water Management Centre, The University of Queensland, St Lucia, QLD 4072, Australia; Toxicological Centre, University of Antwerp, Universiteitsplein 1, Antwerp, 2610, Belgium; International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, QLD 4001, Australia
Recommended Citation:
Gao J.,Li J.,Jiang G.,et al. Stability of alcohol and tobacco consumption biomarkers in a real rising main sewer[J]. Water Research,2018-01-01,138