globalchange  > 气候减缓与适应
DOI: 10.1016/j.watres.2018.02.003
Scopus ID: 2-s2.0-85041427983
Complex pollution of antibiotic resistance genes due to beta-lactam and aminoglycoside use in aquaculture farming
Author: Chen B.; Lin L.; Fang L.; Yang Y.; Chen E.; Yuan K.; Zou S.; Wang X.; Luan T.
Source Publication: Water Research
ISSN: 431354
Publishing Year: 2018
Volume: 134
pages begin: 200
pages end: 208
Language: 英语
Keyword: Antibiotic resistance genes ; Aquaculture ; Extracellular and intracellular DNA ; Sediment
Scopus Keyword: Amides ; Aquaculture ; Enzyme activity ; Genes ; Lead compounds ; Pollution ; Sediments ; Sewage treatment plants ; Sulfur compounds ; Aminoglycosides ; Amoxicillin ; Antibiotic resistance ; Antibiotic resistance genes ; Beta-lactams ; Extracellular ; Macrolides ; Antibiotics ; amoxicillin ; DNA ; gentamicin ; macrolide ; penicillin derivative ; RNA 16S ; sulfonamide ; tetracycline derivative ; amoxicillin ; antiinfective agent ; gentamicin ; penicillin derivative ; abundance ; antibiotic resistance ; antibiotics ; aquaculture ; correlation ; DNA ; gene ; genomics ; plasmid ; public health ; sediment ; antibiotic prophylaxis ; antibiotic resistance ; aquaculture ; Article ; bioinformatics ; bullfrog ; controlled study ; gene ; metagenomics ; microbial community ; nonhuman ; plasmid ; priority journal ; sediment ; water pollution ; analysis ; antibiotic resistance ; bacterial gene ; bacterium ; drug effect ; environmental monitoring ; genetics ; pharmacology ; water pollutant ; Bacteria (microorganisms) ; Rana catesbeiana ; Amoxicillin ; Anti-Bacterial Agents ; Aquaculture ; Bacteria ; Drug Resistance, Microbial ; Environmental Monitoring ; Genes, Bacterial ; Gentamicins ; Metagenomics ; Penicillins ; Plasmids ; Water Pollutants
English Abstract: The prevalence of antibiotic resistance in the modern world has raised global concerns for public health. Establishing relationships between antibiotic use and antibiotic resistance genes (ARGs) is essential to understanding the dissemination and accumulation of ARGs in a human-impacted environment. In this study, ARG profiles in the sediments from a bullfrog farm, where penicillin and amoxicillin (beta-lactams) and gentamicin (aminoglycoside) were used for prophylactic purposes, were analyzed using metagenomic approaches. Analysis of both extracellular and intracellular DNA (eDNA and iDNA) demonstrated that use of the above-mentioned antibiotics led to complex pollution of ARGs not only related to beta-lactams and aminoglycoside but also to sulfonamides, tetracyclines, and macrolides. Most of the ARGs in the sediments from the bullfrog farm were likely carried by plasmids. A significant correlation was observed between the total abundance of ARG-related plasmids and that of plasmid-carrying ARGs. Approximately 85% of the plasmids likely present in the sediment from the bullfrog farm possessed at least 3 ARG subtypes, which conferred the resistance of bacterial hosts to different antibiotic categories. Our results suggest that antibiotics could lead to complex pollution of ARGs unrelated to those administered due to the concurrence of ARGs in the plasmids. © 2018
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被引频次[WOS]:31   [查看WOS记录]     [查看WOS中相关记录]
Document Type: 期刊论文
Appears in Collections:气候减缓与适应

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Affiliation: South China Sea Resource Exploitation and Protection Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China; Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China; School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China

Recommended Citation:
Chen B.,Lin L.,Fang L.,et al. Complex pollution of antibiotic resistance genes due to beta-lactam and aminoglycoside use in aquaculture farming[J]. Water Research,2018-01-01,134
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