DOI: 10.1016/j.watres.2017.12.048
Scopus记录号: 2-s2.0-85041907662
论文题名: Base-catalyzed hydrolysis and speciation-dependent photolysis of two cephalosporin antibiotics, ceftiofur and cefapirin
作者: Ribeiro A.R. ; Lutze H.V. ; Schmidt T.C.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 134 起始页码: 253
结束页码: 260
语种: 英语
英文关键词: Cefapirin
; Ceftiofur
; Hydrolysis
; Photo-transformation
; Speciation
Scopus关键词: Alkalinity
; Degradation
; Disinfection
; Hydrolysis
; Photolysis
; Sewage treatment plants
; Surface waters
; Base-catalyzed hydrolysis
; Cefapirin
; Ceftiofur
; Cephalosporin antibiotics
; Photo-transformation
; Pseudo-first order degradation
; Speciation
; Veterinary antibiotic
; Antibiotics
; cefapirin
; ceftiofur
; river water
; surface water
; antiinfective agent
; ceftiofur
; cephalosporin derivative
; antibiotics
; catalysis
; disinfection
; hydrolysis
; persistence
; pH
; photodegradation
; photolysis
; reaction kinetics
; river water
; speciation (chemistry)
; surface water
; temperature
; transformation
; absorption
; alkalinity
; Article
; controlled study
; degradation kinetics
; disinfection
; drug degradation
; drug stability
; hydrolysis
; hydrolysis kinetics
; photodegradation
; photolysis
; priority journal
; catalysis
; chemistry
; hydrolysis
; kinetics
; pH
; photolysis
; radiation response
; river
; temperature
; water pollutant
; Anti-Bacterial Agents
; Catalysis
; Cephalosporins
; Cephapirin
; Hydrogen-Ion Concentration
; Hydrolysis
; Kinetics
; Photolysis
; Rivers
; Temperature
; Water Pollutants, Chemical
英文摘要: Lately, special attention has been given to veterinary cephalosporin antibiotics due to their broad activity spectrum and significant consumption. Indeed, the determination of hydrolytic and photolytic kinetics provides a better comprehension of the undesired persistence of cephalosporins in aqueous matrices. In this work, the two widely used veterinary antibiotics ceftiofur (CEF) and cefapirin (CEPA) showed high instability under alkaline conditions, degrading in few minutes at pH > 11. In buffered solutions at neutral pH and natural temperature (T = 22 ± 1 °C), both drugs presented moderate stability (t½ = 3 d, CEPA and 1.4 d, CEF). Our study also demonstrated that CEPA and CEF speciation did not significantly influence the direct photolysis rates. Using a simulated water disinfection set-up (λ = 254 nm), all ionic species of CEF and CEPA presented fast and similar pseudo-first order degradation rates, kapp 0.0095 ± 0.0004 and 0.0092 ± 0.001 cm2 mJ-1, respectively. Furthermore, using surface water in hydrolysis experiments, CEF demonstrated significant matrix-dependent stability with a half-life (t½ = 14.7 d) tenfold higher than in buffered solutions. In contrast, CEPA presented a very similar hydrolysis rate in river water (t½ = 4.2 d) and a subtle faster photo-degradation rate in this same matrix (kapp 0.0128 ± 0.001 cm2 mJ-1), highlighting the importance of disinfection radiation for cephalosporin depletion in aqueous environments. © 2017 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112904
Appears in Collections: 气候减缓与适应
There are no files associated with this item.
作者单位: Instrumental Analytical Chemistry and Centre of Water and Environmental Research (ZWU), University of Duisburg-Essen, Universitätsstraße 5, Essen, 45141, Germany; IWW Water Centre, Moritzstraße 26, Mülheim an der Ruhr, 45476, Germany
Recommended Citation:
Ribeiro A.R.,Lutze H.V.,Schmidt T.C.. Base-catalyzed hydrolysis and speciation-dependent photolysis of two cephalosporin antibiotics, ceftiofur and cefapirin[J]. Water Research,2018-01-01,134