DOI: 10.1016/j.watres.2018.01.030
Scopus记录号: 2-s2.0-85041402803
论文题名: Trace analysis of 61 natural and synthetic progestins in river water and sewage effluents by ultra-high performance liquid chromatography–tandem mass spectrometry
作者: Shen X. ; Chang H. ; Sun D. ; Wang L. ; Wu F.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 133 起始页码: 142
结束页码: 152
语种: 英语
英文关键词: Chromatographic separation
; Effluent
; Progestins
; River water
; UPLC-MS/MS
Scopus关键词: Aquatic organisms
; High performance liquid chromatography
; Mass spectrometry
; Risk assessment
; Rivers
; Sewage
; Trace analysis
; Chromatographic separations
; Environmental occurrence
; Environmental water
; Progestins
; River water
; Tandem mass spectrometry
; Ultra-high performance liquid chromatographies
; UPLC-MS/MS
; Effluents
; 6 epi medroxy progesterone 17 acetate
; gestodene
; hydroxyprogesterone
; melengestrol acetate
; mifepristone
; nandrolone derivative
; progesterone derivative
; river water
; unclassified drug
; gestagen
; analytical method
; concentration (composition)
; effluent
; environmental risk
; liquid chromatography
; mass spectrometry
; metabolite
; risk assessment
; river water
; separation
; sewage
; aquatic environment
; Article
; China
; isomer
; limit of detection
; priority journal
; river
; sewage effluent
; tandem mass spectrometry
; ultra performance liquid chromatography
; water analysis
; analysis
; chemistry
; environmental monitoring
; high performance liquid chromatography
; procedures
; river
; sewage
; tandem mass spectrometry
; water pollutant
; Beijing [China]
; China
; Beijing
; Chromatography, High Pressure Liquid
; Environmental Monitoring
; Progestins
; Rivers
; Sewage
; Tandem Mass Spectrometry
; Water Pollutants, Chemical
英文摘要: A broad number of natural and synthetic progestins are widely used in human and veterinary therapies. Although progestins exhibit adverse effects in aquatic organisms, information about environmental occurrence and fate have been limited to several compounds, hampering the accuracy of risk assessments of the compounds. In this study, a selective and sensitive analytical method was established to simultaneously determine 19 natural and 42 synthetic progestins in environmental waters, and the synthetic progestins included 19-nortestosterone, 17α-hydroxyprogesterone and progesterone derivatives. All of the target compounds were effectively separated using an HSS T3 column, and the recoveries for effluent and river samples were 80–115% and 75–105%, respectively. The detection limits for the 61 analytes were in the range of 0.05–0.60 ng/L and 0.03–0.40 ng/L for the effluent and river samples, respectively. The developed method is applied to analyze the target progestogens in sewage effluent and river water samples from Beijing. The detected concentrations of natural progesterone metabolites (3α-hydroxy-5β-tetrahydroprogesterone) were up to 63 times higher than those of the parent compound. Of the three groups of synthetic progestins, the progesterone derivatives were detected for the first time and had the highest concentrations followed by the 19-nortestosterone and 17α-hydroxyprogesterone derivatives. In contrast to previous studies, the predominant derivative compounds of 19-nortestosterone were found to be 19-nortestosterone, gestodene and mifepristone, and those of 17α-hydroxyprogesterone were 6-epi-medroxy progesterone 17-acetate and melengestrol acetate. The toxicities and environmental risk of these emerging progestins deserves more attention in the future. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112935
Appears in Collections: 气候减缓与适应
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作者单位: Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Sciences & Engineering, Beijing Forestry University, Beijing, 100083, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China
Recommended Citation:
Shen X.,Chang H.,Sun D.,et al. Trace analysis of 61 natural and synthetic progestins in river water and sewage effluents by ultra-high performance liquid chromatography–tandem mass spectrometry[J]. Water Research,2018-01-01,133