globalchange  > 气候减缓与适应
DOI: 10.1016/j.watres.2017.11.051
Scopus记录号: 2-s2.0-85036538069
论文题名:
Enantiomeric profiling of chiral illicit drugs in a pan-European study
作者: Castrignanò E.; Yang Z.; Bade R.; Baz-Lomba J.A.; Castiglioni S.; Causanilles A.; Covaci A.; Gracia-Lor E.; Hernandez F.; Kinyua J.; McCall A.-K.; van Nuijs A.L.N.; Ort C.; Plósz B.G.; Ramin P.; Rousis N.I.; Ryu Y.; Thomas K.V.; de Voogt P.; Zuccato E.; Kasprzyk-Hordern B.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 130
起始页码: 151
结束页码: 160
语种: 英语
英文关键词: Chiral drugs ; Enantioselective analysis ; Illicit drugs ; Wastewater-based epidemiology
Scopus关键词: Drug products ; Enantiomers ; Enantioselectivity ; Metabolism ; Physiology ; Chiral drugs ; Chiral signatures ; Enantioselective analysis ; Illicit drug ; Production route ; Spatial and temporal variation ; Spatial variations ; Stereo-selective ; Wastewater disposal ; 3,4 methylenedioxyamphetamine ; 4' methylmethcathinone ; amphetamine ; amphetamine derivative ; biological marker ; illicit drug ; methamphetamine ; midomafetamine ; amphetamine ; methamphetamine ; street drug ; biomarker ; drug ; epidemiology ; metabolism ; spatial variation ; temporal variation ; trafficking ; urban area ; wastewater ; Article ; chirality ; comparative study ; enantiomer ; enantioselectivity ; European ; high performance liquid chromatography ; Northern European ; particle size ; priority journal ; United Kingdom ; urinary excretion ; urine pH ; waste water management ; waste water treatment plant ; wastewater based epidemiology ; analogs and derivatives ; analysis ; chemistry ; city ; drug dependence ; Europe ; human ; procedures ; stereoisomerism ; substance abuse ; waste water ; water pollutant ; Europe ; Norway ; Oslo [Norway] ; United Kingdom ; Amphetamine ; Cities ; Europe ; Humans ; Methamphetamine ; Stereoisomerism ; Street Drugs ; Substance Abuse Detection ; Substance-Related Disorders ; Waste Water ; Water Pollutants, Chemical
英文摘要: The aim of this paper is to present the first study on spatial and temporal variation in the enantiomeric profile of chiral drugs in eight European cities. Wastewater-based epidemiology (WBE) and enantioselective analysis were combined to evaluate trends in illicit drug use in the context of their consumption vs direct disposal as well as their synthetic production routes. Spatial variations in amphetamine loads were observed with higher use in Northern European cities. Enantioselective analysis showed a general enrichment of amphetamine with the R-(−)-enantiomer in wastewater indicating its abuse. High loads of racemic methamphetamine were detected in Oslo (EF = 0.49 ± 0.02). This is in contrast to other European cities where S-(+)-methamphetamine was the predominant enantiomer. This indicates different methods of methamphetamine synthesis and/or trafficking routes in Oslo, compared with the other cities tested. An enrichment of MDMA with the R-(−)-enantiomer was observed in European wastewaters indicating MDMA consumption rather than disposal of unused drug. MDA's chiral signature indicated its enrichment with the S-(+)-enantiomer, which confirms its origin from MDMA metabolism in humans. HMMA was also detected at quantifiable concentrations in wastewater and was found to be a suitable biomarker for MDMA consumption. Mephedrone was only detected in wastewater from the United Kingdom with population-normalised loads up to 47.7 mg 1000 people−1 day−1. The enrichment of mephedrone in the R-(+)-enantiomer in wastewater suggests stereoselective metabolism in humans, hence consumption, rather than direct disposal of the drug. The investigation of drug precursors, such as ephedrine, showed that their presence was reasonably ascribed to their medical use. © 2017
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/113046
Appears in Collections:气候减缓与适应

Files in This Item:

There are no files associated with this item.


作者单位: Department of Chemistry, Faculty of Science, University of Bath, Bath, BA2 7AY, United Kingdom; Division of Biomedical Engineering, School of Engineering, University of Glasgow, Oakfield Road, Glasgow, G12 8LT, United Kingdom; Research Institute for Pesticides and Water, University Jaume I, Avda. Sos Baynat s/n, CastellónE-12071, Spain; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5000, Australia; Norwegian Institute for Water Research (NIVA), Gaustadalleen 21, Oslo, 0349, Norway; IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”, Department of Environmental Health Sciences, Via La Masa 19, Milan, 20156, Italy; KWR Watercycle Research Institute, Chemical Water Quality and Health, P.O. Box 1072, Nieuwegein, BB 3430, Netherlands; Toxicological Center, Department of Pharmaceutical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, Wilrijk-Antwerp, 2610, Belgium; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, CH-8600, Switzerland; Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet, Building 115, Kgs. Lyngby, DK-2800M, Denmark; Department of Chemical Engineering, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom; Process and Systems Engineering Center (PROSYS), Department of Chemical and Biochemical Engineering, Technical University of Denmark, Building 229, Kgs. Lyngby, 2800, Denmark; Queensland Alliance for Environmental Health Science (QAEHS), University of Queensland, 39 Kessels Road, Coopers Plains, QLD 4108, Australia; IBED-University of Amsterdam, Netherlands

Recommended Citation:
Castrignanò E.,Yang Z.,Bade R.,et al. Enantiomeric profiling of chiral illicit drugs in a pan-European study[J]. Water Research,2018-01-01,130
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Castrignanò E.]'s Articles
[Yang Z.]'s Articles
[Bade R.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Castrignanò E.]'s Articles
[Yang Z.]'s Articles
[Bade R.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Castrignanò E.]‘s Articles
[Yang Z.]‘s Articles
[Bade R.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.