DOI: 10.1016/j.jcou.2018.12.011
Scopus记录号: 2-s2.0-85058887672
论文题名: Generation of liposomes using a supercritical carbon dioxide eductor vacuum system: Optimization of process variables
作者: Sharifi F. ; Zhou R. ; Lim C. ; Jash A. ; Abbaspourrad A. ; Rizvi S.S.H.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2019
卷: 29 起始页码: 163
结束页码: 171
语种: 英语
英文关键词: Green technique
; Liposomes
; Nozzle design
; Rapid expansion of supercritical solvent (RESS)
; Supercritical carbon dioxide (SC-CO 2 )
; Vacuum system
Scopus关键词: Carbon dioxide
; Electromagnetic wave emission
; Finite volume method
; Liposomes
; Medical applications
; Mixing
; Nozzle design
; Solvents
; Bernoulli's principle
; Biomedical applications
; Encapsulation efficiency
; Green techniques
; Pressure and temperature
; Supercritical carbon dioxides
; Supercritical solvents
; Vacuum system
; Supercritical fluid extraction
英文摘要: Supercritical CO 2 (SC-CO 2 ) was used to produce liposomes without the aid of any organic solvent. The rapid expansion of supercritical solvent (RESS) strategy and Bernoulli's principle was utilized to introduce cargo solution into a eductor nozzle system to generate liposomes. The pressure of SC-CO 2 and cargo flow rate in the ranges of 12.4 MPa (1800 psig)-17.2 MPa (2500 psig) and 2.2 mL/s -5 mL/s, respectively, were used and the nozzle was positioned at three different levels in the eductor, to investigate their effects on the characteristics of liposomes. The liposomes' sizes became uniform when the pressure was increased from 12.4 MPa to 17.2 MPa. The maximum encapsulation efficiency (EE) was 44% when the nozzle was positioned at the vena contracta right before the beginning of cargo introduction point in the eductor, with cargo solution flow rate of 2.2 mL/s, and the pressure and temperature of 17.2 MPa and 60 °C, respectively. Mixing of the two fluid streams in the eductor nozzle was simulated using Finite Volume Method (FVM). It was found that the mixing was most efficient when the nozzle was positioned right before the beginning of cargo introduction point. The developed system offers an attractive alternative for green generation and use of liposomes in food and biomedical applications. © 2018 Published by Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/117316
Appears in Collections: 气候变化与战略
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Recommended Citation:
Sharifi F.,Zhou R.,Lim C.,et al. Generation of liposomes using a supercritical carbon dioxide eductor vacuum system: Optimization of process variables[J]. Journal of CO2 Utilization,2019-01-01,29