globalchange  > 气候变化事实与影响
DOI: 10.1289/EHP36
论文题名:
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
作者: Olena Gruzieva; 1 Cheng-Jian Xu; 2; 3 Carrie V. Breton; 4 Isabella Annesi-Maesano; 5 Josep M. Antó; 6; 7; 8; 9 Charles Auffray; 10 Stéphane Ballereau; 10 Tom Bell; er; 1; 11 Jean Bousquet; 12 Mariona Bustamante; 6; 8; 9; 13 Marie-Aline Charles; 14 Yvonne de Kluizenaar; 15 Herman T. den Dekker; 16; 17; 18 Liesbeth Duijts; 16; 17; 18 Janine F. Felix; 16; 17; 18 Ulrike Gehring; 19 Mònica Guxens; 6; 8; 9; 20 Vincent V.W. Jaddoe; 16; 17; 18 Soesma A. Jankipersadsing; 2; 3 Simon Kebede Merid; 1 Juha Kere; 21 Ashish Kumar; 1; 22; 23 Nathanael Lemonnier; 10 Johanna Lepeule; 24 Wenche Nystad; 25 Christian Magnus Page; 25 Sviatlana Panasevich; 25 Dirkje Postma; 2 Rémy Slama; 24 Jordi Sunyer; 6; 7; 8; 9 Cilla Söderhäll; 21; 26 Jin Yao; 4 Stephanie J. London; 27 Göran Pershagen; 1; 11 Gerard H. Koppelman; 28*; Erik Melén1; 11; 29*
刊名: Environmental Health Perspectives
ISSN: 0091-6778
出版年: 2017
卷: Volume 125, 期:Issue 1
起始页码: 104
语种: 英语
英文摘要: Background: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation.

Objectives: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation.

Methods: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239).

Results: We found epigenome-wide significant associations [false discovery rate (FDR) p < 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression.

Conclusions: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways.
URL: http://dx.doi.org/10.1289/EHP36
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12109
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Groningen Research Institute for Asthma and COPD (GRIAC), Department of Pulmonology, and 3Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 4Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA; 5Department of Epidemiology of Allergic and Respiratory Diseases, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; 6ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 7IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; 8Universitat Pompeu Fabra (UPF), Barcelona, Spain; 9CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; 10European Institute for Systems Biology and Medicine, Université de Lyon, Lyon, France; 11Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden; 12CHU (Centre Hospitalier Universitaire) Montpellier, University of Montpellier, Montpellier, France; 13Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain; 14Early Origin of the Child’s Health And Development (ORCHAD) team, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS-UMR1153) Inserm, Université Paris Descartes, Villejuif, France; 15The Netherlands Organization for Applied Scientific Research (TNO), Delft, the Netherlands; 16Generation R Study Group, 17Department of Epidemiology, and 18Department of Pediatrics, Erasmus MC (Medical Centre), University Medical Center, Rotterdam, the Netherlands; 19Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; 20Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre–Sophia Children’s Hospital, Rotterdam, the Netherlands; 21Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; 22Unit of Chronic Disease Epidemiology, Department of Public Health Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland; 23University of Basel, Basel, Switzerland; 24Team of Environmental Epidemiology, Inserm and University Grenoble-Alpes, IAB (U1209), Grenoble, France; 25Division for Physical and Mental health, Norwegian Institute of Public Health, Oslo, Norway; 26Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden; 27Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 28Groningen Research Institute for Asthma and COPD (GRIAC), Beatrix Children’s Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 29Sachs Children’s Hospital, Stockholm, Sweden

Recommended Citation:
Olena Gruzieva,1 Cheng-Jian Xu,2,et al. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure[J]. Environmental Health Perspectives,2017-01-01,Volume 125(Issue 1):104
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