DOI: 10.1016/j.watres.2019.01.051
Scopus记录号: 2-s2.0-85061669095
论文题名: Effects of ozonation on the activity of endotoxin and its inhalation toxicity in reclaimed water
作者: Ren Y. ; Kong J. ; Xue J. ; Shi X. ; Li H. ; Qiao J. ; Lu Y.
刊名: Water Research
ISSN: 431354
出版年: 2019
卷: 154 起始页码: 153
结束页码: 161
语种: 英语
英文关键词: Endotoxin
; Inflammation
; Ozonation
; Polymorphonuclear cell
; Reclaimed water
英文摘要: Aerosolized reclaimed water can cause inflammatory responses in lung after inhalation, and endotoxin has been identified as the main inducer. Since the effects of disinfection treatments on endotoxins had conflicting results, this study explored the changes of endotoxin activity and inflammation inducing ability of reference endotoxin, gram-negative bacteria solutions and reclaimed water after ozonation respectively, and found that LAL assay based endotoxin activity and mouse inhalation exposure based inflammation examination had inconsistent results. The excessive ozone could not remove the endotoxin activity, but was able to reduce the inflammation inducing ability of free endotoxin. When treating on gram-negative strains, ozone first released the cell-bound endotoxin and caused the dramatic increase of endotoxin activity. But for the inflammatory response, despite the rapid increase at the very beginning, it immediately dropped back with further ozonation. The endotoxin aggregate size was proposed as a key regulator of the toxicity of endotoxin, which was modified by ozone oxidation. In real reclaimed water, insufficient ozone significantly enhanced the inflammatory response, but when the ozone dosages were large enough, the inflammation could be drawn back to the original level, which was consistent with the observations from pure endotoxin and bacteria. This work demonstrates that the endotoxin activity cannot predict the endotoxin-induced toxicity of ozone treated water, and low dosage of ozone treatment may even increase the health risk of reclaimed water. © 2019 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/121948
Appears in Collections: 气候变化事实与影响
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作者单位: State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua UniversityBeijing 100084, China; Department of Chemistry, Tsinghua UniversityBeijing 100084, China
Recommended Citation:
Ren Y.,Kong J.,Xue J.,et al. Effects of ozonation on the activity of endotoxin and its inhalation toxicity in reclaimed water[J]. Water Research,2019-01-01,154