DOI: 10.1016/j.watres.2019.01.018
Scopus记录号: 2-s2.0-85061244850
论文题名: Approach for analytical characterization and toxicological assessment of ozonation products in drinking water on the example of acesulfame
作者: Buchner E.-M. ; Happel O. ; Schmidt C.K. ; Scheurer M. ; Schmutz B. ; Kramer M. ; Knauer M. ; Gartiser S. ; Hollert H.
刊名: Water Research
ISSN: 431354
出版年: 2019
起始页码: 357
结束页码: 368
语种: 英语
英文关键词: Acesulfame
; Drinking water
; Genotoxicity
; Germany
; Ozonation
; Risk assessment
; Transformation products
Scopus关键词: Ion chromatography
; Ozone
; Ozonization
; Potable water
; Risk assessment
; Sugar substitutes
; Testing
; Water quality
; Acesulfame
; Analytical characterization
; Artificial sweeteners
; Genotoxicities
; Germany
; Monitoring and control
; Toxicological assessment
; Transformation products
; Ozone water treatment
; acesulfame
; drinking water
; oxidizing agent
; ozone
; analytical method
; antibiotics
; assessment method
; concentration (composition)
; drinking water
; enrichment
; genotoxicity
; ozonation
; risk assessment
; toxicity
; transformation
; water quality
; water treatment
; Ames test
; analytic method
; aquatic environment
; Article
; comet assay
; concentration (parameter)
; controlled study
; crystallization
; decomposition
; genotoxicity
; ion exchange chromatography
; micronucleus test
; monitoring
; nonhuman
; ozonation
; priority journal
; quantitative analysis
; retention time
; risk assessment
; Germany
英文摘要: The monitoring and control of drinking water quality is generally important as it significantly contributes to the health of the population. In this context, particular attention has to be paid to the use of treatment techniques during drinking water treatment. It is known that the formation of reaction products (transformation products) has to be taken into account when oxidizing agents such as ozone are used. Different transformation products are classified as critical to health and require analytical examination. The risk assessment for previously unknown transformation products can be difficult as far as not all transformation products are present as single substances or the individual substances are not present in a sufficient high concentration or cannot be isolated from the original solution. The aim of this work is to show exemplarily the identification and quantification of ozonation products (OPs) after ozonation and their toxicological characterization, using the artificial sweetener acesulfame. It was shown that OPs can be fully characterized using ion chromatography in combination with different detection systems. A major OP could be recovered as a pure substance by crystallization and direct genotoxicological testing was possible without previous enrichment processes. Acesulfame samples of different concentrations in ultrapure and in drinking water after ozonation were tested in several genotoxicity tests. These tests revealed genotoxic effects of acesulfame after ozonation in ultrapure water in several genotoxicological test systems (micronucleus test, umu test, Ames-fluctuation-test and comet assay). In contrast, the crystallized ozonation product OP168 did not show any positive effects. Therefore, it seems likely that the observed effect was caused by the second major product OP170. However, a sufficiently large amount of analytically pure substance OP170 could not be obtained. It was also shown that the rate of the OP170 formation in drinking water is significantly lower than in ultrapure water and that ozonation in drinking water did not induce genotoxic effects. © 2019 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/121968
Appears in Collections: 气候变化事实与影响
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作者单位: Water Laboratory, RheinEnergie AG, Parkgürtel 24, Köln, 50823, Germany; Department of Ecosystem Analysis, Institute for Environmental Research, ABBt—Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, Aachen, 52074, Germany; DVGW-Technologiezentrum Wasser (TZW), Karlsruher Straße 84, Karlsruhe, 76139, Germany; Hydrotox GmbH, Bötzinger Straße 29, Freiburg i.Br, 79111, Germany
Recommended Citation:
Buchner E.-M.,Happel O.,Schmidt C.K.,et al. Approach for analytical characterization and toxicological assessment of ozonation products in drinking water on the example of acesulfame[J]. Water Research,2019-01-01