DOI: 10.1016/j.watres.2018.12.054
Scopus记录号: 2-s2.0-85060100831
论文题名: Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact
作者: Jaén-Gil A. ; Castellet-Rovira F. ; Llorca M. ; Villagrasa M. ; Sarrà M. ; Rodríguez-Mozaz S. ; Barceló D.
刊名: Water Research
ISSN: 431354
出版年: 2019
起始页码: 171
结束页码: 180
语种: 英语
英文关键词: Fungal biomass
; Fungal water treatment
; Metoprolol
; Metoprolol acid
; Suspect screening
; Transformation products
Scopus关键词: Biodegradation
; Biological water treatment
; Biomass
; Biomolecules
; Degradation
; Effluents
; Fluidized beds
; Fungi
; Hospitals
; Metabolites
; Biotransformation pathways
; Fluidized bed bioreactors
; Fungal biomass
; Metoprolol
; Persistent metabolites
; Pharmaceutical compounds
; Trametes versicolor
; Transformation products
; Wastewater treatment
; metoprolol tartrate
; purified water
; biodegradation
; biomass
; bioreactor
; biotransformation
; ecotoxicology
; fungus
; hospital sector
; medicine
; metabolite
; sorption
; wastewater
; water treatment
; Article
; biodegradation
; bioluminescence
; biotransformation
; chemical oxygen demand
; collisionally activated dissociation
; comparative study
; concentration (parameter)
; controlled study
; ecotoxicity
; fungal biomass
; Ganoderma lucidum
; hospital waste
; metabolite
; Pleurotus ostreatus
; priority journal
; retention time
; toxicity testing
; Trametes versicolor
; waste water management
; Fungi
; Ganoderma lucidum
; Pleurotus ostreatus
; Trametes versicolor
英文摘要: Hospital wastewater (HWW) effluents represent an important source of contaminants such as pharmaceutical compounds and their human metabolites. To better evaluate dedicated treatment of hospital effluents for pollutant mitigation, not only the parent compounds should be considered but also the intermediates generated during treatment. The metabolite metoprolol acid (MTPA) has been found in urban wastewaters at higher concentration than its parent compound metoprolol (MTP), being more recalcitrant to biodegradation. The aim of this study was to investigate degradation, transformation and sorption of the β-blocker MTP, and its recalcitrant metabolite MTPA, during water treatment based on the fungi Ganoderma lucidum, Trametes versicolor and Pleurotus ostreatus. Fourteen intermediates were identified in MTP biotransformation while five of them also attributed to MTPA biodegradation and two to MTPA only. Their identification allowed their correlation in separate biotransformation pathways suggested. The highest degradation rate of metoprolol (up to 51%) and metoprolol acid (almost 77%) was found after 15-days treatment with Ganoderma lucidum, with an increase in toxicity up to 29% and 4%, respectively. This fungus was further selected for treating real HWW in a batch fluidized bed bioreactor (FBB). Treated wastewater and fungal biomass samples were used to evaluate the distribution of the target compounds and the intermediates identified between solid and liquid phases. While similar elimination capabilities were observed for the removal of metoprolol, and even higher for its persistent metabolite metoprolol acid, the extent on compound transformation diminished considerably compared with the study treating purified water: a high level of the persistent α-HMTP and TP240 were still present in effluent samples (15% and 6%, respectively), being both TPs present at high proportion (up to 28%) in fungal biomass. This is the first time that pharmaceutical TPs have been investigated in the fungal biomass. © 2019 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/122018
Appears in Collections: 气候变化事实与影响
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作者单位: Catalan Institute for Water Research (ICRA),
H
2
O Building
, Scientific and Technological Park of the University of Girona, Emili Grahit 101, Girona, E-17003, Spain; Chemical, Biological and Environmental Engineering Department, Universitat Autònoma de Barcelona (UAB), Bellaterra, E-08193, Spain; Water and Soil Quality Research Group, Department of Environmental Chemistry, (IDAEA-CSIC), Jordi Girona 18-26, Barcelona, E-08034, Spain
Recommended Citation:
Jaén-Gil A.,Castellet-Rovira F.,Llorca M.,et al. Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact[J]. Water Research,2019-01-01