DOI: 10.1016/j.watres.2018.11.010
Scopus记录号: 2-s2.0-85057543608
论文题名: Seasonal occurrence and fate of chiral pharmaceuticals in different sewage treatment systems in Hong Kong: Mass balance, enantiomeric profiling, and risk assessment
作者: Ruan Y. ; Wu R. ; Lam J.C.W. ; Zhang K. ; Lam P.K.S.
刊名: Water Research
ISSN: 431354
出版年: 2019
起始页码: 607
结束页码: 616
语种: 英语
英文关键词: Enantiomer
; Mass balance
; Pharmaceutical
; Risk assessment
; Seasonal
; Sewage
Scopus关键词: Antibiotics
; Bioassay
; Biodegradation
; Drug products
; Effluents
; Enantiomers
; Sewage
; Sewage treatment plants
; Stereochemistry
; Aquatic environments
; Chiral pharmaceuticals
; Discharged effluents
; Ecotoxicological assessment
; Mass balance
; Mass balance analysis
; Primary removal mechanism
; Seasonal
; Risk assessment
; atenolol
; chloramphenicol
; metoprolol
; venlafaxine
; chemical mass balance
; drug
; ecotoxicology
; environmental fate
; risk assessment
; seasonal variation
; sewage treatment
; wastewater treatment plant
; activated sludge
; aquatic environment
; Article
; biodegradation
; chirality
; controlled study
; ecotoxicology
; effluent
; enantiomer
; Hong Kong
; human
; hydrophobicity
; limit of detection
; physical chemistry
; priority journal
; risk assessment
; seasonal variation
; sedimentation
; sewage treatment plant
; solid
; stereoisomerism
; China
; Hong Kong
; Hong Kong Island
; Victoria Harbour
; Protozoa
英文摘要: Concern about the presence of chiral pharmaceuticals in the environment from wastewater discharge is mounting. In this work, the occurrence and fate of atenolol, metoprolol, venlafaxine, and chloramphenicol, including 10 different stereoisomers, were investigated in sewage and sludge from diverse treatment processes in 4 sewage treatment plants (STPs) in Hong Kong via 4 sampling campaigns over a period of 2 years. The average amounts of individual pharmaceuticals entering the STPs ranged from 4.91 g/d to 6290 g/d, with sludge carrying much lower amounts than the discharged effluent. Mass balance analysis revealed that: larger quantities of these pharmaceuticals were released during the dry seasons, biodegradation was the primary removal mechanism for atenolol and chloramphenicol, and the removal via primary sedimentation and disinfection processes was insignificant (<30%). Selectivity toward R-(+)-atenolol, S-(−)-metoprolol, and R-(−)-venlafaxine was mostly found across secondary-treated effluent samples. Sold as an enantiopure pharmaceutical in R,R-para-form, chloramphenicol was preferentially eliminated after biological process. This is the first study on the occurrence of chloramphenicol enantiomers in the aquatic environment. Ecotoxicological assessment indicated that atenolol and metoprolol could pose risks to marine fish in effluent-receiving waters (i.e., the western waters and Victoria Harbor) of Hong Kong, while R-(+)-atenolol could pose a risk to protozoans five times higher than the S-(−)-enantiomer. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/122124
Appears in Collections: 气候变化事实与影响
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作者单位: State Key Laboratory of Marine Pollution (SKLMP), Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity, City University of Hong Kong, Hong Kong; Department of Chemistry, City University of Hong Kong, Hong Kong; Department of Science and Environmental Studies, The Education University of Hong of Kong, Hong Kong
Recommended Citation:
Ruan Y.,Wu R.,Lam J.C.W.,et al. Seasonal occurrence and fate of chiral pharmaceuticals in different sewage treatment systems in Hong Kong: Mass balance, enantiomeric profiling, and risk assessment[J]. Water Research,2019-01-01