globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1510334
论文题名:
Ingested Nitrate and Breast Cancer in the Spanish Multicase–Control Study on Cancer (MCC-Spain)
作者: Nadia Espejo-Herrera; 1; 2; 3 Esther Gracia-Lavedan; 1; 2; 3 Marina Pollan; 3; 4; 5 Nuria Aragonés; 3; 4; 5 Elena Boldo; 3; 4; 5 Beatriz Perez-Gomez; 3; 4; 5 Jone M. Altzibar; 3; 6 Pilar Amiano; 3; 6 Ana Jiménez Zabala; 6 Eva Ardanaz; 3; 7; 8 Marcela Guevara; 3; 7; 8 Antonio J. Molina; 9 Juan Pablo Barrio; 9 Ines Gómez-Acebo; 3; 10 Adonina Tardón; 3; 11 Rosana Peiró; 3; 12 Maria Dolores Chirlaque; 3; 13; 14 Margarita Palau; 15 Montse Muñoz; 16 Laia Font-Ribera; 1; 2; 3; 17 Gemma Castaño-Vinyals; 1; 2; 3; 17 Manolis Kogevinas; 1; 2; 3; 17; Cristina M. Villanueva1; 2; 3; 17
刊名: Environmental Health Perspectives
ISSN: 0091-7002
出版年: 2016
卷: Volume 124, 期:Issue 7
起始页码: 1042
语种: 英语
英文摘要: Background: Ingested nitrate leads to endogenous formation of N-nitroso compounds that are breast carcinogens in animals, but human evidence is limited.

Objective: We evaluated ingested nitrate as a risk factor for breast cancer (BC) in a multicase–control study.

Methods: Hospital-based incident BC cases and population-based controls were recruited in eight Spanish regions in 2008–2013; participants provided residential and water consumption from 18 years of age and information on known BC risk factors. Long-term nitrate levels (1940–2010) were estimated and linked with residential histories and water consumption to calculate waterborne ingested nitrate (milligrams/day). Dietary ingested nitrate (milligrams/day) was calculated using food frequency questionnaires and published dietary nitrate contents. Interactions with endogenous nitrosation factors and other variables were evaluated. A total of 1,245 cases and 1,520 controls were included in the statistical analysis.

Results: Among the study regions, average ± SD waterborne ingested nitrate ranged from 2.9 ± 1.9 to 13.5 ± 7.5 mg/day, and dietary ingested nitrate ranged from 88.5 ± 48.7 to 154 ± 87.8 mg/day. Waterborne ingested nitrate was not associated with BC overall, but among postmenopausal women, those with both high nitrate (> 6 vs. < 2.6 mg/day) and high red meat intake (≥ 20 vs. < 20 g/day) were more likely to be cases than women with low nitrate and low red meat intake (adjusted odds ratio = 1.64; 95% confidence interval: 1.08, 2.49; overall interaction p-value = 0.17). No association was found with dietary nitrate.

Conclusions: Waterborne ingested nitrate was associated with BC only among postmenopausal women with high red meat consumption. Dietary nitrate was not associated with BC regardless of the animal or vegetable source or of menopausal status.
URL: http://dx.doi.org/10.1289/ehp.1510334
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12333
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1ISGlobal Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 2Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain; 3CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 4Cancer and Environmental Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain; 5Cancer Epidemiology Research Group, Oncology and Hematology Area, Instituto de Investigación Sanitaria (IIS) Puerta De Hierro, Madrid, Spain; 6Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain; 7Navarra Public Health Institute, Pamplona, Spain; 8Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; 9Research Group in Gene–Environment–Health Interactions (GIIGAS), University of Leon, León, Spain; 10IDIVAL (Valdecilla Institute of Research), University of Cantabria, Santander, Spain; 11Oncology Institute IUOPA (Institute of Oncology of Asturias), Universidad de Oviedo, Asturias, Spain; 12Centre for Research in Public Health, Valencia, Spain; 13Department of Epidemiology, Murcia Health Council, IMIB-Arrixaca, Murcia, Spain; 14Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain; 15Division of Public Health Quality and Innovation, Health Ministry of Spain, Madrid, Spain; 16Translational Genomics and Targeted Therapeutics in Solid Tumors (IDIBAPS), Hospital Clinic, Barcelona, Spain; 17IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

Recommended Citation:
Nadia Espejo-Herrera,1,2,et al. Ingested Nitrate and Breast Cancer in the Spanish Multicase–Control Study on Cancer (MCC-Spain)[J]. Environmental Health Perspectives,2016-01-01,Volume 124(Issue 7):1042
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