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In the context of global warming, the impact of changes in meteorological elements on respiratory diseases cannot be ignored. In the meteorological comfort ecosystem, the impact of typical meteorological factors on the human respiratory system is analyzed in the paper, using the meteorological data of the city and the emergency and outpatient visits of respiratory diseases in the top three hospitals from 2007 to 2012. The analysis model of the impact of the meteorological comfort ecosystem on the human respiratory system is constructed to analyze the relationship between major meteorological elements and human respiratory diseases, as well as the distribution characteristics of mortality in patients with respiratory diseases. The results of this model show that human respiratory diseases are most significantly related to mean temperature, minimum temperature, and maximum temperature, and respiratory disease mortality has the distinct seasonality in time distribution. In the summer half year, the climatic environment of low pressure, high temperature and multiple precipitations has the milder effect on the respiratory tract, and it is not easy to cause death of patients with respiratory diseases. In the winter half year, there are climate characteristics with relatively high humidity and short sunshine hours, and the mortality rate of respiratory diseases is on the rise.