Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients
Background: The relationship between traffic-related air pollution (TRAP) and risk factors for cardiovascular disease needs to be better understood in order to address the adverse impact of air pollution on human health.
Objective: We examined associations between roadway proximity and traffic exposure zones, as markers of TRAP exposure, and metabolic biomarkers for cardiovascular disease risk in a cohort of patients undergoing cardiac catheterization.
Methods: We performed a cross-sectional study of 2,124 individuals residing in North Carolina (USA). Roadway proximity was assessed via distance to primary and secondary roadways, and we used residence in traffic exposure zones (TEZs) as a proxy for TRAP. Two categories of metabolic outcomes were studied: measures associated with glucose control, and measures associated with lipid metabolism. Statistical models were adjusted for race, sex, smoking, body mass index, and socioeconomic status (SES).
Results: An interquartile-range (990 m) decrease in distance to roadways was associated with higher fasting plasma glucose (β = 2.17 mg/dL; 95% CI: –0.24, 4.59), and the association appeared to be limited to women (β = 5.16 mg/dL; 95% CI: 1.48, 8.84 compared with β = 0.14 mg/dL; 95% CI: –3.04, 3.33 in men). Residence in TEZ 5 (high-speed traffic) and TEZ 6 (stop-and-go traffic), the two traffic zones assumed to have the highest levels of TRAP, was positively associated with high-density lipoprotein cholesterol (HDL-C; β = 8.36; 95% CI: –0.15, 16.9 and β = 5.98; 95% CI: –3.96, 15.9, for TEZ 5 and 6, respectively).
Conclusion: Proxy measures of TRAP exposure were associated with intermediate metabolic traits associated with cardiovascular disease, including fasting plasma glucose and possibly HDL-C.
1Duke Molecular Physiology Institute, and 2Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA; 3School of Natural Resources and the Environment, University of Michigan, Ann Arbor, Michigan, USA; 4National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency (EPA), Chapel Hill, North Carolina, USA; 5National Exposure Research Laboratory, U.S. EPA, Research Triangle Park, North Carolina, USA; 6Alion Science and Technology Inc., Durham, North Carolina, USA; 7Epidemiologic Research and Information Center, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
Recommended Citation:
Cavin K. Ward-Caviness,1 William E. Kraus,1,et al. Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients[J]. Environmental Health Perspectives,2015-01-01,Volume 123(Issue 10):1007