globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1510345
论文题名:
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research
作者: Gill Langley; 1 Christopher P. Austin; 2 Anil K. Balapure; 3 Linda S. Birnbaum; 4 John R. Bucher; 5 Julia Fentem; 6 Suzanne C. Fitzpatrick; 7 John R. Fowle III; 8 Robert J. Kavlock; 9 Hiroaki Kitano; 10 Brett A. Lidbury; 11 Alysson R. Muotri; 12 Shuang-Qing Peng; 13 Dmitry Sakharov; 14 Troy Seidle; 15 Thales Trez; 16 Alex; er Tonevitsky; 17 Anja van de Stolpe; 18 Maurice Whelan; 19; Catherine Willett20
刊名: Environmental Health Perspectives
ISSN: 0091-7328
出版年: 2015
卷: Volume 123, 期:Issue 11
起始页码: A268
语种: 英语
英文摘要: Biomedical developments in the 21st century provide an unprecedented opportunity to gain a dynamic systems-level and human-specific understanding of the causes and pathophysiologies of disease. This understanding is a vital need, in view of continuing failures in health research, drug discovery, and clinical translation. The full potential of advanced approaches may not be achieved within a 20th-century conceptual framework dominated by animal models. Novel technologies are being integrated into environmental health research and are also applicable to disease research, but these advances need a new medical research and drug discovery paradigm to gain maximal benefits. We suggest a new conceptual framework that repurposes the 21st-century transition underway in toxicology. Human disease should be conceived as resulting from integrated extrinsic and intrinsic causes, with research focused on modern human-specific models to understand disease pathways at multiple biological levels that are analogous to adverse outcome pathways in toxicology. Systems biology tools should be used to integrate and interpret data about disease causation and pathophysiology. Such an approach promises progress in overcoming the current roadblocks to understanding human disease and successful drug discovery and translation. A discourse should begin now to identify and consider the many challenges and questions that need to be solved.
URL: https://ehp.niehs.nih.gov/15-10345
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12657
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Research and Toxicology Department, Humane Society International, London, United Kingdom; 2National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA; 3Division of Biochemistry, CSIR–Central Drug Research Institute, Lucknow, India; 4National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP), NIH, DHHS, Research Triangle Park, North Carolina, USA; 5Division of NTP, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA; 6Unilever R&D, Safety and Environmental Assurance Centre (SEAC), Sharnbrook, Bedfordshire, United Kingdom; 7Office of the Center Director, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Maryland, USA; 8Science to Inform LLC, Pittsboro, North Carolina, USA; 9Office of Research and Development, U.S. Environmental Protection Agency, Washington DC, USA; 10Systems Biology Institute, Tokyo, Japan; 11Genomics and Predictive Medicine, John Curtin School of Medical Research, Australian National University, Canberra, Australia; 12University of California, San Diego, School of Medicine, Department of Pediatrics/Rady Children’s Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, La Jolla, California, USA; 13Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China; 14Scientific Research Centre Bioclinicum, Moscow, Russia; 15Research and Toxicology Department, Humane Society International, Montréal, Quebec, Canada; 16Institute of Science and Technology, Federal University of Alfenas, Alfenas, Brazil; 17National Center of Medical Radiological Research, Obninsk, Russia; 18Philips Research, Eindhoven, the Netherlands; 19Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy; 20Regulatory Toxicology, Risk Assessment and Alternatives, Humane Society of the United States, Washington DC, USA.

Recommended Citation:
Gill Langley,1 Christopher P. Austin,2 Anil K. Balapure,et al. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research[J]. Environmental Health Perspectives,2015-01-01,Volume 123(Issue 11):A268
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