WEST-NILE-VIRUS
; DENGUE HEMORRHAGIC-FEVER
; NECROSIS-FACTOR-ALPHA
; FC-GAMMA-RIIA
; SINGLE NUCLEOTIDE POLYMORPHISMS
; NONSTRUCTURAL PROTEIN NS1
; CHIKUNGUNYA VIRUS
; EVOLUTIONARY EPIDEMIOLOGY
; CUBAN POPULATION
; PROTECTIVE ROLE
WOS学科分类:
Virology
WOS研究方向:
Virology
英文摘要:
Mosquito-borne diseases constitute a large portion of infectious diseases, causing more than 700,000 deaths annually. Mosquito-transmitted viruses, such as yellow fever, dengue, West Nile, chikungunya, and Zika viruses, have re-emerged recently and remain a public health threat worldwide. Global climate change, rapid urbanization, burgeoning international travel, expansion of mosquito populations, vector competence, and host and viral genetics may all together contribute to the re-emergence of arboviruses. In this brief review, we summarize the host and viral genetic determinants that may enhance infectivity in the host, viral fitness in mosquitoes and viral transmission by mosquitoes.