TRANSPOSABLE ELEMENTS
; EUROPEAN EEL
; GENE-EXPRESSION
; AMERICAN EEL
; GROWTH
; EPIGENETICS
; ROSTRATA
; TRANSCRIPTOME
; RESISTANCE
; MATURATION
WOS学科分类:
Environmental Sciences
WOS研究方向:
Environmental Sciences & Ecology
英文摘要:
Understanding how organisms cope with global change is a major question in many fields of biology. Mainly, understanding the molecular mechanisms supporting rapid phenotypic changes of organisms in response to stress and linking stress-induced molecular events to adaptive or adverse outcomes at the individual or population levels remain a major challenge in evolutionary biology, ecology or ecotoxicology. In this view, the present study aimed to test (i) whether environmental factors, especially pollutants, can trigger changes in the activity of retrotransposons (RTs) in wild fish and (ii) if changes in RT DNA methylation or transcription levels can be linked to modifications at the individual level. RTs are genetic elements that have the ability to replicate and integrate elsewhere in the genome. Although RTs are mainly quiescent during normal development, they can be experimentally activated under life threatening conditions, affecting the fitness of their host. Wild eels were collected in four sampling sites presenting differing levels of contamination. The methylation level and the transcriptional activity of two RTs and two genes involved in development and cell differentiation were analyzed in fish liver in addition to the determination of fish contaminants levels and diverse growth and morphometric indices. An up-regulation of RTs associated to lower methylation levels and lower growth indices were observed in highly contaminated fish. Our results suggest that RT activation in fish experiencing stress conditions could have both detrimental and beneficial implications, affecting fish growth but promoting resistance to environmental stressors such as pollutants. (C) 2018 Elsevier Ltd. All rights reserved.
1.Univ Bordeaux, CNRS, EPOC, F-5805 Talence, France 2.Univ Bordeaux, CNRS, Observ Aquitain Sci Univers, UMS 2567 POREA, Allee Geoffroy St Hilaire, F-33615 Pessac, France 3.Inst Natl Rech Sci & Technol Environm & Agr IRSTE, Equipe Poissons Migrateurs Amphihalins PMA, Cestas, France 4.INRS, Ctr Eau Terre Environm, 490 Rue La Couronne, Quebec City, PQ G1K 9A9, Canada
Recommended Citation:
Pierron, Fabien,Daffe, Guillemine,Lambert, Patrick,et al. Retrotransposon methylation and activity in wild fish (A-anguilla): A matter of size[J]. ENVIRONMENTAL POLLUTION,2019-01-01,245:494-503