Nowhere has the impact of scientific misinformation been more profound than on the issue of climate change in the United States. Effective responses to this multifaceted problem have been slow to develop, in large part because many experts have not only underestimated its impact, but have also overlooked the underlying institutional structure, organizational power and financial roots of misinformation. Fortunately, a growing body of sophisticated research has emerged that can help us to better understand these dynamics and provide the basis for developing a coordinated set of strategies across four related areas (public inoculation, legal strategies, political mechanisms and financial transparency) to thwart large-scale misinformation campaigns before they begin, or after they have taken root.