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Assessment of potential forests' threats due to multiple global change components is urgently needed since increasing exposure to them could undermine their future persistence. We aim to assess the risks to the persistence of monospecific forests in Western Mediterranean Europe posed by climate change, fire, and land-use changes (i.e., deforestation) in the short and medium terms (horizon 2040). We specifically evaluate whether the degree of risk related to the likelihood of hazard occurrence varies depending on seral stage, tree species, and climate gradients. We performed the risk assessment on forests of Catalonia (NE Spain) through a combination of correlative and process-based modeling approaches and future global change scenarios. Overall, climate suitability of forests showed a general decrease by 2040, with the exception of xeric Pinus halepensis forests mainly distributed in the driest climate of the study area. Forest stands dominated by low drought-tolerant species were at higher risk of losing climatic suitability than forests dominated by Mediterranean species. The highest fire and deforestation risks were predicted for forest stands in dry climate where human pressures are higher. Nevertheless, high deforestation risk was also attained outside the driest areas. Deforestation risk was lower in old-growth than in younger stands, whereas old-growth forests in the Wet climate or dominated by Pinus sylvestris were projected to be at higher fire risk than younger forests. Our results suggest that conservation actions should target forest stands in dry climate. Moreover, old-growth forest stands should also be prioritized due to their particular sensitivity to disturbances and their high ecological value.