globalchange  > 过去全球变化的重建
DOI: 10.1002/sim.8067
WOS记录号: WOS:000465355700003
论文题名:
Assessing health care interventions via an interrupted time series model: Study power and design considerations
作者: Cruz, Maricela1; Gillen, Daniel L.1; Bender, Miriam2; Ombao, Hernando1,3
通讯作者: Ombao, Hernando
刊名: STATISTICS IN MEDICINE
ISSN: 0277-6715
EISSN: 1097-0258
出版年: 2019
卷: 38, 期:10, 页码:1734-1752
语种: 英语
英文关键词: change-point detection ; complex interventions ; patient satisfaction ; power analysis ; segmented regression ; time series
WOS关键词: COMPLEX INTERVENTIONS ; REGRESSION ; QUALITY
WOS学科分类: Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability
WOS研究方向: Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
英文摘要:

The delivery and assessment of quality health care is complex with many interacting and interdependent components. In terms of research design and statistical analysis, this complexity and interdependency makes it difficult to assess the true impact of interventions designed to improve patient health care outcomes. Interrupted time series (ITS) is a quasi-experimental design developed for inferring the effectiveness of a health policy intervention while accounting for temporal dependence within a single system or unit. Current standardized ITS methods do not simultaneously analyze data for several units nor are there methods to test for the existence of a change point and to assess statistical power for study planning purposes in this context. To address this limitation, we propose the Robust Multiple ITS (R-MITS) model, appropriate for multiunit ITS data, that allows for inference regarding the estimation of a global change point across units in the presence of a potentially lagged (or anticipatory) treatment effect. Under the R-MITS model, one can formally test for the existence of a change point and estimate the time delay between the formal intervention implementation and the over-all-unit intervention effect. We conducted empirical simulation studies to assess the type one error rate of the testing procedure, power for detecting specified change-point alternatives, and accuracy of the proposed estimating methodology. R-MITS is illustrated by analyzing patient satisfaction data from a hospital that implemented and evaluated a new care delivery model in multiple units.


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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/138269
Appears in Collections:过去全球变化的重建

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作者单位: 1.Univ Calif Irvine, Dept Stat, Irvine, CA USA
2.Univ Calif Irvine, Sue & Bill Gross Sch Nursing, Irvine, CA USA
3.King Abdullah Univ Sci & Technol, Stat Program, Thuwal, Saudi Arabia

Recommended Citation:
Cruz, Maricela,Gillen, Daniel L.,Bender, Miriam,et al. Assessing health care interventions via an interrupted time series model: Study power and design considerations[J]. STATISTICS IN MEDICINE,2019-01-01,38(10):1734-1752
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