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Floods are the climatic factors that cause more significant impacts on transportation infrastructures. This circumstance could get worse, taking into account climate change effects. The literature points out different adaptation measures to minimize the possible increasing effects caused by climate change. Among them is the improvement of the vulnerability of a transport network and Emergency Management Systems. The effective management of emergencies is of vital importance to minimize the potential damage resulting from a catastrophe. Given such circumstances, analysis of the vulnerability of networks is a technique whose results highlight deficiencies and serve as support for future decisions concerning the transformation of the network or the installation of new emergency centers. The main objective of this research is to highlight the vulnerability of the road network in a variety of multi-contingency scenarios related to flooding and to identify the optimal location for a new emergency management center based on that analysis. The results obtained could be used in urban planning tasks to improve the resilience of urban areas in the face of an increase in flood episodes caused by climate change.