Background: The relationship between air borne particulate matter ≤10 μm (PM10) exposure and pregnancy-induced hypertension (PIH) is inconclusive. Few studies have been conducted, and fewer were conducted in areas with high levels of PM10. Methods: To examine the association between PM10 and PIH by different exposure time windows during pregnancy, we analyzed data from a birth cohort study conducted in Lanzhou, China including 8 745 pregnant women with available information on air pollution during pregnancy. A total of 333 PIH cases (127 gestational hypertension (GH) and 206 preeclampsia (PE)) were identified. PM10 daily average concentrations of each subject were calculated according to the distance between home/work addresses and monitor stations using an inverse-distance weighting approach. Results: Average PM10 concentration over the duration of entire pregnancy was significantly associated with PIH (OR = 1.12, 95%CI: 1.02, 1.23 per 10 μg m−3 increase), PE (OR = 1.16, 95%CI: 1.03, 1.30 per 10 μg m−3 increase), late onset PE (OR = 1.17, 95% CI: 1.03, 1.32 per10 μg m−3 increase), and severe PE (OR = 1.25, 95% CI: 1.06, 1.48 per 10 μg m−3 increase). Average PM10 during the first 12 gestational weeks was associated with the risk of GH (OR = 1.10, 95% CI: 1.00, 1.21 per 10 μg m−3 increase), and PM10 exposure before 20 gestational weeks was associated with the risk of severe PE (OR = 1.14, 95% CI: 1.01, 1.30 per 10 μg m−3 increase). Conclusions: We found that high level exposure to ambient PM10 during pregnancy was associated with an increased risk of PIH, GH and PE and that the strength of the association varied by timing of exposure during pregnancy.
Central South University, School of Public Health, Changsha, Hunan, People’s Republic of China;Yale University, School of Public Health, New Haven, CT, USA;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Academy of Environmental Sciences, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Yale University, School of Public Health, New Haven, CT, USA;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Yale University, School of Public Health, New Haven, CT, USA;Yale University, School of Public Health, New Haven, CT, USA;Sichuan University School of Public Health, Chengdu, Sichuan, People’s Republic of China;Yale University, School of Public Health, New Haven, CT, USA;Yale University, School of Forestry and Environmental Studies, New Haven, CT, USA;National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA;Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, People’s Republic of China;Yale University, School of Public Health, New Haven, CT, USA
Recommended Citation:
Xin Huang,Jie Qiu,Yaqun Zhang,et al. Ambient air pollutant PM10 and risk of pregnancy-induced hypertension in urban China[J]. Environmental Research Letters,2015-01-01,10(8)