globalchange  > 全球变化的国际研究计划
DOI: 10.1016/j.celrep.2019.07.028
WOS记录号: WOS:000480691300008
论文题名:
Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization
作者: Huggins, Matthew A.1; Sjaastad, Frances V.2; Pierson, Mark1; Kucaba, Tamara A.3; Swanson, Whitney3; Staley, Christopher4; Weingarden, Alexa R.5,6; Jensen, Isaac J.7; Danahy, Derek B.7; Badovinac, Vladimir P.7,8,9; Jameson, Stephen C.1,2,10,11; Vezys, Vaiva2,10,11,12; Masopust, David2,10,11,12; Khoruts, Alexander2,10,13; Griffith, Thomas S.2,3,10,11,14; Hamilton, Sara E.1,2,10,11
通讯作者: Griffith, Thomas S. ; Hamilton, Sara E.
刊名: CELL REPORTS
ISSN: 2211-1247
出版年: 2019
卷: 28, 期:7, 页码:1729-+
语种: 英语
WOS关键词: CD8(+) T-CELLS ; TOLL-LIKE RECEPTORS ; GUT MICROBIOTA ; HOMEOSTATIC PROLIFERATION ; LISTERIA-MONOCYTOGENES ; SEPTIC SHOCK ; SEPSIS ; INNATE ; INFECTION ; RESPONSES
WOS学科分类: Cell Biology
WOS研究方向: Cell Biology
英文摘要:

Microbial exposures can define an individual's basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the immune system, including increased circulating phagocytes and elevated inflammatory cytokines. How these differences in the basal immune state influence the acute response to systemic infection is unclear. Cohoused mice exhibit enhanced protection from virulent Listeria monocytogenes (LM) infection, but increased morbidity and mortality to polymicrobial sepsis. Cohoused mice have more TLR2(+) and TLR4(+) phagocytes, enhancing recognition of microbes through pattern-recognition receptors. However, the response to a TLR2 ligand is muted in cohoused mice, whereas the response to a TLR4 ligand is greatly amplified, suggesting a basis for the distinct response to Listeria monocytogenes and sepsis. Our data illustrate how microbial exposure can enhance the immune response to unrelated challenges but also increase the risk of immunopathology from a severe cytokine storm.


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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/145391
Appears in Collections:全球变化的国际研究计划

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作者单位: 1.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
2.Univ Minnesota, Microbiol Immunol & Canc Biol PhD Program, Minneapolis, MN 55455 USA
3.Univ Minnesota, Dept Urol, Minneapolis, MN 55455 USA
4.Univ Minnesota, Dept Surg, Box 242 UMHC, Minneapolis, MN 55455 USA
5.Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA
6.Univ Minnesota, BioTechnol Inst, St Paul, MN 55108 USA
7.Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA USA
8.Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA
9.Univ Iowa, Dept Microbiol & Immunol, Iowa City, IA USA
10.Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA
11.Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA
12.Univ Minnesota, Dept Microbiol & Immunol, Minneapolis, MN USA
13.Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA
14.Minneapolis VA Hlth Care Syst, Minneapolis, MN 55417 USA

Recommended Citation:
Huggins, Matthew A.,Sjaastad, Frances V.,Pierson, Mark,et al. Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization[J]. CELL REPORTS,2019-01-01,28(7):1729-+
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