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The objective in this review was to discuss the importance of maize currently and the crucial role it may play in the future for food production in scenarios of water shortage, as well as the importance of conserving its landrace cultivars, which have a considerable portion of the reserve of genetic variability. Maize plants, when exposed to water deficit, may develop physiological, morphological, biochemical and anatomical adaptation mechanisms. With the aid of genetic improvement, characteristics that impart tolerance are fixed in plants through conventional methods. In this context, 'Tuxpeno Sequia' cultivars were developed in Mexico, while in Africa, one of the most important strategies was the development of 'DT' (Drought-tolerant) cultivars. In the United States, one of the most important processes was the development of PionerAquamax (R) hybrids, while in Brazil, it was the development of cultivars with the 'Maya Latente' gene. Through genetic transformation, the hybrid 'MON 87460' was developed. However, it should be mentioned that, for a cultivar to be well accepted by producers, besides having one or more adaptation characteristics, it must have a high grain yield. Biotechnological tools such as the use of molecular markers, genetic transformation, and modeling through bioinformatics, associated with conventional selection, will be fundamental to guarantee the advancement of water deficit tolerance in maize.