Quantitative simulation and analysis of vegetation canopy interception in a large scale is of great significance to reveal water-sediment changing mechanism under combined influences of climate change and human activities. Hekouzhen-Tongguan region in the middle reaches of the Yellow River was taken as the study area. Quantity of vegetation canopy interception in 1984, 1995 and 2010 were simulated by using models coupled with spatial data such as remote sensing data. The main data used in the study include precipitation data from weather stations and GLASS- LAI remote sensing data. Results show that vegetation coverage has increased since the 1980s, especially since the end of 1990s due to ecological restoration policy. And vegetation canopy interception has varied since the 1980s. The average yearly precipitation intercepted by canopy in 1984, 1995 and 2010 were 19.57 mm, 13.66 mm and 22.68 mm respectively, with the interception rate of 3.24%, 3.32% and 4.92% accordingly. It is found that vegetation canopy interception has been influenced by precipitation characteristics and vegetation synthetically in the study area, where precipitation plays a determinant factor. And LAI is the main factor affecting yearly vegetation interception variation since the 1980s.