The changes of lake levels could keep a record of lake variation on the Tibetan Plateau. Under the background of global warming in recent years, it is of importance to understand regional responses to climate changes by revealing the lake level variation of the inland lakes on the Tibetan Plateau. The paper obtained the time-series of the five typical lake areas and levels from 1972 to 2012 in the south-central Tibetan Plateau, and used the multisensor remote sensing data to analyze the variation of lake levels in recent 40 years. The results show that the three inland lakes (Pumo Yumco, Taro Co and Zhari Namco)expanded by 0.89 m, 0.70 m and 0.40 m in water level, respectively, while the two lakes (Peiku Co and Mapang Yumco)presented a decreasing tendency in water level. On the whole, the period 2000-2012 experienced remarkable changes compared with the preceding period (1976-1999). In term of spatial changes, the lakes of Peiku Co and Mapang Yumco, located in south fringe of the Tibetan Plateau, have shown the consistency in lake level changes, and so are the lakes of Taro Co and Zhari Namco in the southwestern part of central Tibetan Plateau.