The method of linear regression trend analysis and Mann Kendall and cumulative distance equal mutation testing method were adopted to study the temperature and precipitation in 1961-2011 in the eastern region of Xinjiang,revealing the fact of climate change in the region and trend,and to discusses its impact on regional ecological environment.The study results show that the eastern region in Xinjiang and each site the annual average temperature of the four seasons was rising over the past 50 years,the rate of warming nearly 50 years was more than three times of the global warming rate reported by the IPCC the fourth time,the rate of warming was up to 0.42 ℃/10 a,warming rate is higher than that of China and the northwest arid areas,and the abrupt change of increasing temperature occurred in 1993.The winter temperatures among the four seasons had the largest contribution to the temperature rise.Annual rainfall in eastern region of Xinjiang workstations was increasing with decreasing during the study period and it presented more significantly increased trend at Balikun station,increase rate was 9.77 mm/10 a,the annual precipitation presented a weak downward trend at Shisanjianfang station,and the decline rate was 1.97 mm/10 a,the annual precipitation at the rest of the stations had increased,but the trend was not significant,and humidifying mutation happened in 1976.Temperature of the eastern region in Xinjiang rose,precipitation increased.The overall development was towards to warming and humidity,which had the significant impact on the change of water resources in the region and ecological environment such as wind and dust storm weather events.The further research for evaluation on the exact is necessary in this region.