Daily meteorological data,collected from 19stations within Guizhou province over 19602013, were used to calculate the standard precipitation-evaporation index(SPEI)in annual,seasonal and sixmonth time scales.The spatial and temporal distribution characteristics of drought and regional response to climate change in Guizhou province in recent 54years(from 1960to 2013)were analyzed under global climate change.Results indicated that:the drought stations proportions and drought intensities at the annual, spring,summer and autumn scales exhibited upward trend over the past 54years with a better continuity in the future;The drought stations proportions appeared as the features of the local and all regional drought,and the drought intensity showed a moderate level at seasonal and annual scales.Drought occurred in high frequency at stage of spring and summer.Spring drought happened frequently in northwest of Guizhou,in contrast,while summer drought happened frequently in the northeast and southeast parts. During the crop growth stage,the region had a drought trend,especially a serious drought tendency after 2001.Spatially,the high frequency of crop-growing seasons drought region tended to move to the west. Precipitation,relative humidity and the accumulative sunshine were the main factors affecting the meteorological drought in Guizhou province.