Under the status of trace settlement and higher urban security fortification, sea-level rise, due to global warming, must be considered for the control of land subsidence in Shanghai. In this paper, sea-level rise was taken as one of considerations for land subsidence control in Shanghai. Based on the monitoring results of flood-control project settlement and regional land subsidence, as well as sea-level rise impact on defense capability of flood prevention walls, it was found that regional land subsidence had a significant effect on flood-control project settlement, and the superposition of ground settlement. Sea-level rise would further reduce drainage capacity of urban flood or tide prevention projects. Then the control strategies were proposed, such as monitoring and earlywarning mechanism for major public constructions, zoning control in different regions, better utilization and management for groundwater resources, improving networks for monitoring land subsidence.