Global climate change, which featured as increasing temperature, increased precipitation intensity and more frequent extreme weather events, will affect the security, the stability, the reliability and the durability of the engineering by impacting major engineering facilities and important auxiliary equipment, and it will have an effect on major projects' operating efficiency and economic benefit. The climate change also influences the technical standards and engineering measures of the major projects. Major projects including the Qinghai-Tibet railway, the high-speed railway, the water resources and hydropower project are taken as typical engineering systems to describe impacts of climate change on major projects of China. The thermal balance of frozen soil environment along the Qinghai-Tibet railway (highway) is easy to break, while the environment of permafrost is difficult to recover. The surface temperature, annual precipitation, typhoons will be changed and the extreme weather and climate events will occur more frequently in the future climate, which will affect the service life of high speed railway infrastructure and the transportation order and so on. The future spatial and temporal distribution of water resources are changed due to the temperature and precipitation in the climate change background, which will influence the water allocation and scheduling, water resource utilization and hydrological risk management.