A simulated climate warming experiment was conducted to evaluate the combined effects of elevated temperature and CO_2 concentration on the bioaccumulation of Cd in wheat seedlings. The aim of this study was to explore the process and the mechanism of the crop responses to the stress of Cd in future climate scenarios. The results showed that compared to control,elevated temperature and CO_2 increased Cd bioaccumulation factor by 1. 983. 37 times in the shoots,by 1. 902.48 times in the roots. Moreover,Cd concentration was also significantly increased with the increase of temperature and CO_2 concentration in subcellular compartments of roots and shoots of wheat seedlings. The largest proportion of Cd was found in the soluble fractions which were the main storage site for Cd in wheat seedling cells. The increase of temperature and CO_2 had no significant effect on the proportional distribution of Cd in the subcellular fractions. In addition,the root - to - shoot translocation of Cd increased significantly under the highest temperature and CO_2 treatment conditions. It is likely to further strengthen the negative effects of climate warming on ecosystem, human food security and other aspects on multiple levels.