Supported by the technologies of the remote sensing and geographic information system, the data derived from remote sensing images in 1985, 1995, 2000 and 2014 were used in this study, and the methods of landscape ecology were used to analyze the landscape pattern change of the wetlands in the in Jiaozhou Bay, and the driving factors were discussed. The results showed that the total area of wetlands increased from 792 km2 in 1985 to 896 km~2 in 1995 and then decreased to 804 km2 in 2014; the average area of the patches reduced from 2.968 km~2 in 1985 to 0.305 km2 in 2014, while the index of the edge density increased from 21.70 in 1985 to 30.56 in 2014, which showed that the fragmentation was becoming more serious; influenced by the building of the reservoirs, aquaculture, salt-obtaining, sea reclamation and climate change etc., the centroids of various types of the wetlands have changed greatly. Among those, the change of the aquaculture area was the most obvious. The centroid of the aquaculture area moved 9.8 km to the west from 1985 to 2000, and then moved 12.7 km to the northeast from 2000 to 2014. The change of landscape pattern of the wetlands in the study area might be greatly impacted by the human factors such as urbanization, policy and so on.