Meteorological data from 1961 to 2015 in Huaihe river were used to analyze time series trend of temperature,precipitation and sunshine duration in Huaihe river basin by the M-K and R/S method, then point mutations were calculated. It was found that: ①The average annual temperature of Huaihe river showed a rising trend with a statistical significance, and most of these sites'temperature mutations appeared in the 1990s; the temperature rise in the south of the basin is higher than that in the north region; viewed from the Hurst exponent, the future average annual temperature of the Huaihe river will be continued to rise with no significance. ②The Huaihe river basin's average annual precipitation showed a decreasing trend and multiple precipitation mutations occurred in the time; the precipitation of each site changed with no statistical significance,but all appeared multiple mutations; from Hurst exponent, the future of the basin average annual precipitation will occur rise situation. ③The average annual sunshine duration in Huaihe river basin showed a trend of decline,but the change was not significant; from the spatial distribution, each sites had declined significantly; from the point of Hurst index, the average annual sunshine duration in the future will continue to decline.