Water security problem has become a major bottleneck constraining the sustainable socioeconomic development, and is also a significant strategy of China. Using the analysis method of water resources sensitivity and resistance to stress,including the secondary indicators of water resources development and utilization rate,water crowding and water function zones compliance, this paper will analyze the issues of supply and demand of water resources and water environment. The results show that the Jia- odong rivers, Xiaoqing River and Tuhaimajia River are most sensitive third-class river basins; while the southern regions of Shandong Province are less sensitive to climate change. The resistance of water resources from all third-class regions is not significantly higher, especially Dawen River, Tuhaimajia River, East Lake, West Lake,the Canal Zone and Yishu River area having a poor adaptation to deal with supply and demand of water resources; while the adaptive ability of Jiaodong rivers and Xiaoqing River is relative higher. In addition to Jiaodong rivers,the development and utilization rate of the other third-class regions is more than 50%,especially as the utilization rate of Tuhaimajia River and Xiaoqing River is greater than 100%. The regions of "severe water shortage or extreme water shortage" are concentrated in Lake West, Tuhaimajia River and East Lake River Basins. Each region's length ratio is generally lower than 55%.