Glacier volume change has significant influence on sea level, regional water resources, eco-environment and social economy. However, it is very difficult to carry out in-situ measurement. The main aim of this study is to make quantitative investigation on the scaling relation between glacier volume change and area change based on the ice volume estimation of nine glaciers in the Tianshan Mountains. Then, the scaling relation between glacier volume change and area change, which is suited for current climate condition and response process of glaciers, is established by using statistical method in order to estimate glacier volume change from glacier area change. It is found that there is a linear relation between glacier reserve change and glacier area change,with a determination coefficient between 0.67 and 0.70. The determination coefficient does not improve much as adding samples of glaciers in the other mountain areas. The reason may be that, on the one hand, there are errors in the glacier change monitoring and volume estimating, on the other hand, the sensitivity of glacier change to climate change, which depended on the glacier type, size and their regional differentia, is not the same. Therefore, in further study, it is necessary to focus on not only glacier volume estimation, but also on the glacier type and its regional differentia.