Variations of vegetation play an important influence on regional ecosystem stability and ecological environment. In this paper,the MOD13A3 data were used to investigate the vegetation coverage in the Qilian Mountains during 2000 - 2015. The digital elevation model (DEM) and land cover classification were also applied to divide the interval altitude and different lands use to further discuss spatiotemporal pattern and variations of vegetation coverage,and then to analyze the climatic response by using meteorological data. The results presented that the vegetation coverage pattern in the Qilian Mountains is more in the east and less in the west, consistent with the spatial distribution of precipitation. The bush wood and alpine sparse meadow had grown better from 2000 through 2008,after then,they had gone worse. Meanwhile,alpine sylvosteppe and alpine meadow had become better. The whole vegetation coverage in the Qilian Mountains is increasing,which might be caused by the climatic changing to warmer and wetting.