The winter wheat varieties and their possibility planting region were going through remarkable changes under climate change, which will have an effect on the pattern of regional agricultural water surplus and deficit. Based on the multi-model datasets of three representation concentration pathways (RCP) emission scenarios from IPCC5,the possibility changes of winter wheat varieties as well as their planting region, crop planting pattern in the Huang-HuaiHai Region during 2011-2059 were analyzed. The variations of wheat evapotranspiration, irrigation amount and regional agricultural water surplus and deficit were assessed by VIP (soil-Vegetation-atmosphere Interface Processes) model at sub-basin scale. The results show that due to the temperature rising, the possibility planting area for winter wheat will increase in the northern part of the study area, and decrease in the southern part. The strong winterness wheat will be gradually displaced by the winterness and weak winterness varieties. Compared with the baseline, the possibility planting area for winter wheat in the Huang-Huai-Hai Region will decrease by 0.4%-11.8% in the 2050s. The expansion of wheat possibility planting area in the northern part of the study area may aggravate water shortage of the Haihe River basin. The gap between agricultural water demand and supply may increase by 3.7* 10~8-34.0* 10~8 m~3 in the Haihe basin in the 2050s. Under global warming, water will replace energy and become the major factor restricting wheat planting area expansion in the Haihe basin. In the southern part of the study area, the wheat planting area shrinkage will provide an opportunity for the expansion of double cropping rice planting. In this situation, the rainfall surplus will decrease correspondingly. The research results can provide a scientific reference for the rational distribution of winter wheat in the Huang-Huai-Hai Region.