Using the NCEP/NCAR reanalysis data, the sea surface temperature (SST) data of Hadley Center/the United Kingdom Meteorological Office during 1948 to 2003 and singular value decomposition (SVD) method, we investigate the leading coupled modes between the SST anomalies and the atmospheric circulation anomalies in the East Asia-subtropical North Pacific region. The results show that the global mid-low latitude air-sea interaction is the coupling of an organic whole, regardless of its annual or decadal change there is synchronized coupling. This also gives us a new idea of global changes in air-sea coupling. The results of extracted composite analysis of SST anomaly and wind anomaly of the basic air-sea coupled mode in positive and negative anomalous years show that when the sea water of the equatorial eastern Pacific is warm, the tropical Indian Ocean and tropical Atlantic sea water is simultaneously warm, while at the same time the SST of the area from the tropical western Pacific to mid-latitude Pacific is generally cool. The sea water in both of the east and west of the Pacific coast is generally warm. In terms of the Indian Ocean, the large sea area of 30~50 °S of the southern Africa has obvious negative SST anomalies. There are obvious negative SST anomalies in the sea areas north of 30 °N on the east coast of the North America and south of 30 °S on the east coast of the South America. When the SST of the eastern equatorial Pacific is cool, the reverse is true for the SST distribution of each of the oceans.