With the increase of the haze weather, the medical community has become increasingly deep understanding of haze. We found through clinical practice and literature review that some characteristics between haze and epidemic disease are similar. Haze is the same as pestilential pathogen which belongs to the category of exopathy that the essence is dampness toxin. They all have damp and toxic properties. Because of air is dry in most areas of China in winter and spring, the haze is often mixed with dryness to form the characteristics of dampness, dryness and toxin that together attack the human body. Its pathogenesis is closely related to climatic change and social factors. The essential difference between haze and epidemic disease is whether it has infectivity. For the characteristics of the diseases caused by haze, we put forward the fundamental method of treatment was strengthening body resistance and eliminating evil and summed up a series of prescriptions. This article will be try to explore the characteristics and treatment principles of the diseases caused by haze from epidemic disease and expect to provide references for clinical application.