The semi-arid region,as a key part of global land,plays an important role in climate change.In the process of modern climate change,the semi-arid region is significantly affected by local human activities,showing remarkable expansion and obvious decadal variations.In this paper,we summarized the studies of the land-atmosphere interaction in the semi-arid regions in recent years,and major land surface observation plans.We put emphasis on energy balance,water cycle,carbon cycle in land-atmosphere interaction of climate change,and their performance in historical simulation and future prediction.The prediction results illustrate that new character of landatmosphere interaction will appear as the drying of drylands in the future.Therefore,it is necessary to deepen the understanding of land-atmosphere interaction and move forward energetically on research in regional climate from different aspects.